Reactome | PXLP-BCAT2 [mitochondrial matrix]

PXLP-BCAT2 [mitochondrial matrix]

Stable Identifier

R-HSA-70703

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

branched-chain amino acid aminotransferase, mitochondrial, apoenzyme, BCAT2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15382 BCAT2

Gene Names

BCAT2, BCATM, BCT2, ECA40

Chain

transit peptide:1-27, chain:28-392

Reference Genes

BioGPS Gene:587 BCAT2

COSMIC (genes):BCAT2 BCAT2

CTD Gene:587 BCAT2

dbSNP Gene:587 BCAT2

ENSEMBL:ENSG00000105552 BCAT2

HGNC:977 BCAT2

KEGG Gene (Homo sapiens):587 BCAT2

Monarch:587 BCAT2

NCBI Gene:587 BCAT2

OMIM:113530 BCAT2

UCSC:O15382 BCAT2

Reference Transcript

Other Identifiers

0003390288

11727544_a_at

16874082

203576_at

3867419

3867420

3867422

3867423

3867424

3867425

3867428

3867429

3867430

3867433

3867434

41111_at

587

8038202

A_23_P101551

A_23_P90163

GE59360

GO:0003674

GO:0003824

GO:0004084

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005759

GO:0006520

GO:0006549

GO:0006550

GO:0006551

GO:0006573

GO:0008150

GO:0008483

GO:0008652

GO:0009056

GO:0009058

GO:0009081

GO:0009082

GO:0009083

GO:0009098

GO:0009099

GO:0010817

GO:0016740

GO:0043226

GO:0044281

GO:0052654

GO:0052655

GO:0052656

GO:1990830

ILMN_1695110

PH_hs_0026804

TC19001697.hg

TC19002539.hg

U62739_at

g4502374_3p_at

Participant Of

hasComponent

BCAT2 dimer [mitochondrial matrix]

Inferred To

Dmel\CG1673 [mitochondrial matrix] (Drosophila melanogaster)

BAT1 [mitochondrial matrix] (Saccharomyces cerevisiae)

BCAT2 [mitochondrial matrix] (Canis familiaris)

bcat-1 [mitochondrial matrix] (Caenorhabditis elegans)

PXLP-BCAT2 [mitochondrial matrix] (Bos taurus)

PXLP-BCAT2 [mitochondrial matrix] (Caenorhabditis elegans)

BAT2 [mitochondrial matrix] (Saccharomyces cerevisiae)

bcaA [mitochondrial matrix] (Dictyostelium discoideum)

Homologues of PXLP-BCAT2 [mitochondrial matrix] (Caenorhabditis elegans)

Homologues of PXLP-BCAT2 [mitochondrial matrix] (Saccharomyces cerevisiae)

bcat2 [mitochondrial matrix] (Danio rerio)

bcat2 [mitochondrial matrix] (Xenopus tropicalis)

eca39 [mitochondrial matrix] (Schizosaccharomyces pombe)

Bcat2 [mitochondrial matrix] (Mus musculus)

Bcat2 [mitochondrial matrix] (Rattus norvegicus)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 229

Coordinate

229

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

NP_001158245.1, NP_001271254.1, NP_001181.2

OpenTargets

ENSG00000105552

GeneCards

O15382

HPA

ENSG00000105552-BCAT2

Ensembl

ENSP00000440973, ENST00000316273, ENSP00000322991, ENSG00000105552, ENST00000545387

PRO

O15382

Orphanet

24360

HMDB Protein

HMDBP00516

PDB

2HGW, 5I5S, 5MPR, 5BWW, 5BWV, 5HNE, 6PRX, 1EKV, 1KT8, 5I5Y, 5I60, 5I5X, 5BWT, 2A1H, 5BWU, 1EKP, 2HHF, 5I5W, 5I5V, 2HG8, 5BWR, 5CR5, 1EKF, 5I5U, 5I5T, 1KTA, 5BWX, 2HGX, 2HDK

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963)	0.564	2

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