Reactome | PXLP-BCAT2 [mitochondrial matrix]

PXLP-BCAT2 [mitochondrial matrix]

Stable Identifier

R-HSA-70703

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

branched-chain amino acid aminotransferase, mitochondrial, apoenzyme, BCAT2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15382 BCAT2

Gene Names

BCAT2, BCATM, BCT2, ECA40

Chain

transit peptide:1-27, chain:28-392

Reference Genes

BioGPS Gene:587 BCAT2

COSMIC (genes):BCAT2 BCAT2

CTD Gene:587 BCAT2

dbSNP Gene:587 BCAT2

ENSEMBL:ENSG00000105552 BCAT2

HGNC:977 BCAT2

KEGG:hsa:587 BCAT2

Monarch:587 BCAT2

NCBI Gene:587 BCAT2

OMIM:113530 BCAT2

UCSC:O15382 BCAT2

Reference Transcript

Other Identifiers

11727544_a_at

16874082

203576_PM_at

203576_at

215654_PM_at

215654_at

3867419

3867420

3867421

3867422

3867423

3867424

3867425

3867426

3867427

3867428

3867429

3867430

3867433

3867434

3867435

3867436

3867437

3867438

3867439

3867440

3867441

3867442

41111_at

587

8038202

A_23_P101551

A_23_P90163

GE59360

GO:0003824

GO:0004084

GO:0005515

GO:0005654

GO:0005739

GO:0005759

GO:0006520

GO:0006549

GO:0006550

GO:0006551

GO:0006573

GO:0006629

GO:0008483

GO:0008652

GO:0009081

GO:0009082

GO:0009083

GO:0009098

GO:0009099

GO:0010817

GO:0016740

GO:0043226

GO:0050048

GO:0052654

GO:0052655

GO:0052656

GO:1990830

HMNXSV003052812

Hs.306660.0.S1_3p_at

ILMN_1695110

PH_hs_0026804

PH_hs_0039244

TC19001697.hg

TC19001698.hg

TC19002539.hg

U62739_at

g4502374_3p_at

p26056

Participates

as a component of

BCAT2 dimer [mitochondrial matrix] (Homo sapiens)

Inferred To

BAT1 [mitochondrial matrix] (Saccharomyces cerevisiae)

BCAT2 [mitochondrial matrix] (Canis familiaris)

BCAT2 [mitochondrial matrix] (Sus scrofa)

bcat-1 [mitochondrial matrix] (Caenorhabditis elegans)

Bcat [mitochondrial matrix] (Drosophila melanogaster)

PXLP-BCAT2 [mitochondrial matrix] (Bos taurus)

PXLP-BCAT2 [mitochondrial matrix] (Mus musculus)

PXLP-BCAT2 [mitochondrial matrix] (Rattus norvegicus)

bcaA [mitochondrial matrix] (Dictyostelium discoideum)

bcat2 [mitochondrial matrix] (Danio rerio)

bcat2 [mitochondrial matrix] (Xenopus tropicalis)

eca39 [mitochondrial matrix] (Schizosaccharomyces pombe)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 229

Coordinate

229

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

NP_001181.2, NP_001158245.1, NP_001271254.1

Guide to Pharmacology - Targets

2893

OpenTargets

ENSG00000105552

ENSEMBL

ENSG00000105552, ENSP00000322991, ENST00000316273, ENSP00000440973, ENST00000545387

HPA

ENSG00000105552-BCAT2

GeneCards

BCAT2

PRO

O15382

Pharos - Targets

O15382

HMDB Protein

HMDBP00516

PDB

5BWV, 5BWW, 5BWX, 2HGW, 5BWR, 5CR5, 2HHF, 5BWU, 5BWT, 1KT8, 1EKV, 1EKF, 1EKP, 2HDK, 6PRX, 5I60, 5I5U, 5I5V, 5I5Y, 5MPR, 5I5W, 5I5X, 2A1H, 2HGX, 1KTA, 2HG8, 5I5T, 5I5S, 5HNE

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.713	5
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	4
UniProt:Q96G04 EEF2KMT	1	EEF2KMT [cytosol] (R-HSA-8876690)	0.527	3