GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc

Stable Identifier
R-HSA-70369
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
UDP-galactose <=> UDP-glucose
Locations in the PathwayBrowser
General
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Cytosolic UDP-galactose 4-epimerase catalyzes the interconversion of UDP-D-galactose and UDP-D-glucose (Schulz et al. 2004). The active form of the enzyme is a homodimer with one molecule of bound NAD+ per monomer (Thoden et al. 2000).

Literature References
PubMed ID Title Journal Year
15175331 Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase

Schulz, JM, Watson, AL, Sanders, R, Ross, KL, Thoden, JB, Holden, HM, Fridovich-Keil, JL

J Biol Chem 2004
10801319 Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase

Thoden, JB, Wohlers, TM, Fridovich-Keil, JL, Holden, HM

Biochemistry 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
UDP-glucose 4-epimerase activity of GALE:NAD+ dimer [cytosol]
Physical Entity
Activity
Orthologous Events