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Switching of origins to a post-replicative state
Stable Identifier
R-HSA-69052
DOI
10.3180/REACT_2148.1
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
General
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Switching of origins to a post-replicative state involves the removal of Orc1 from chromatin, CDK-mediated phosphorylation and removal of Cdc6, and the rearrangement and mobilization of Mcm2-7.
Participants
Events
Orc1 removal from chromatin
(Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6
(Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork
(Homo sapiens)
CDT1 binds geminin
(Homo sapiens)
Participates
as an event of
Synthesis of DNA (Homo sapiens)
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Switching of origins to a post-replicative state (Rattus norvegicus)
Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
Switching of origins to a post-replicative state (Schizosaccharomyces pombe)
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Switching of origins to a post-replicative state (Xenopus tropicalis)
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