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Phosphorylated Cdc6 is exported from the nucleus
Stable Identifier
R-HSA-69006
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Phosphorylated Cdc6 is exported from the nucleus (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Phosphorylated Cdc6 is exported from the nucleus (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In this reaction, 1 molecule of 'phosphorylated Cdc6' is translocated from nucleoplasm to cytosol.
This movement of the molecule occurs through the 'nuclear pore'.
Literature References
PubMed ID
Title
Journal
Year
10339564
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.
Jiang, W
,
Wells, NJ
,
Hunter, T
Proc Natl Acad Sci U S A
1999
Participants
Input
p-CDC6 [nucleoplasm]
(Homo sapiens)
Output
p-CDC6 [cytosol]
(Homo sapiens)
Participates
as an event of
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Orthologous Events
Phosphorylated Cdc6 is exported from the nucleus (Bos taurus)
Phosphorylated Cdc6 is exported from the nucleus (Caenorhabditis elegans)
Phosphorylated Cdc6 is exported from the nucleus (Canis familiaris)
Phosphorylated Cdc6 is exported from the nucleus (Danio rerio)
Phosphorylated Cdc6 is exported from the nucleus (Dictyostelium discoideum)
Phosphorylated Cdc6 is exported from the nucleus (Drosophila melanogaster)
Phosphorylated Cdc6 is exported from the nucleus (Gallus gallus)
Phosphorylated Cdc6 is exported from the nucleus (Mus musculus)
Phosphorylated Cdc6 is exported from the nucleus (Plasmodium falciparum)
Phosphorylated Cdc6 is exported from the nucleus (Rattus norvegicus)
Phosphorylated Cdc6 is exported from the nucleus (Saccharomyces cerevisiae)
Phosphorylated Cdc6 is exported from the nucleus (Schizosaccharomyces pombe)
Phosphorylated Cdc6 is exported from the nucleus (Sus scrofa)
Phosphorylated Cdc6 is exported from the nucleus (Xenopus tropicalis)
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