The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin

Stable Identifier
R-HSA-68950
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
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At the beginning of this reaction, 1 molecule of 'dTTP', 1 molecule of 'dGTP', 1 molecule of 'dATP', 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex', and 1 molecule of 'dCTP' are present. At the end of this reaction, 1 molecule of 'RNA primer-DNA primer:origin duplex' is present.

This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed DNA polymerase activity' of 'DNA polymerase alpha:primase'.

Literature References
PubMed ID Title Journal Year
6094569 Purification of a DNA polymerase-DNA primase complex from calf thymus glands

Rafter, E, Bollum, FJ, Chang, LM, Augl, C

J. Biol. Chem. 1984
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Output
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Catalyst Activity

DNA-directed DNA polymerase activity of DNA polymerase alpha:primase [nucleoplasm]

Physical Entity
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
Activity
DNA-directed DNA polymerase activity (GO:0003887)
Orthologous Events
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Bos taurus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Caenorhabditis elegans)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Canis familiaris)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Danio rerio)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Dictyostelium discoideum)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Drosophila melanogaster)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Gallus gallus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Mus musculus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Plasmodium falciparum)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Rattus norvegicus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Saccharomyces cerevisiae)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Schizosaccharomyces pombe)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Xenopus tropicalis)
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