The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin

Stable Identifier
R-HSA-68913
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'DNA polymerase alpha:primase:DNA polymerase alpha:origin complex', and 1 molecule of 'NTP' are present. At the end of this reaction, 1 molecule of 'DNA polymerase epsilon', and 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed RNA polymerase activity' of 'DNA polymerase alpha:primase'.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA-directed 5'-3' RNA polymerase activity of DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events