PDCL promotes formation of G-beta:G-gamma heterodimers

Stable Identifier
R-HSA-6814418
Type
Reaction [binding]
Species
Homo sapiens
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G-protein gamma subunit binds folded G-protein beta subunits 1-4 associated with PDCL (PhLP1) after release from TRiC/CCT, resulting in formation of the G-protein beta:gamma complex (Lukov et al. 2006, Plimpton et al. 2015). In Pdcl-depleted mouse rods, G-protein beta:gamma dimer formation is decreased 50-fold, leading to 10-fold reduction in light sensitivity (Lai et al. 2013).

Literature References
PubMed ID Title Journal Year
16717095 Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex

Lukov, GL, Baker, CM, Ludtke, PJ, Hu, T, Carter, MD, Hackett, RA, Thulin, CD, Willardson, BM

J. Biol. Chem. 2006
23637185 Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors

Lai, CW, Kolesnikov, AV, Frederick, JM, Blake, DR, Jiang, L, Stewart, JS, Chen, CK, Barrow, JR, Baehr, W, Kefalov, VJ, Willardson, BM

J. Neurosci. 2013
15889144 Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly

Lukov, GL, Hu, T, McLaughlin, JN, Hamm, HE, Willardson, BM

EMBO J. 2005
25675501 Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly

Plimpton, RL, Cuellar, J, Lai, CW, Aoba, T, Makaju, A, Franklin, S, Mathis, AD, Prince, JT, Carrascosa, JL, Valpuesta, JM, Willardson, BM

Proc. Natl. Acad. Sci. U.S.A. 2015
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