Reactome | GOLGA4 [cytosol]

GOLGA4 [cytosol]

Stable Identifier

R-HSA-6813884

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Golgin-245, Golgin subfamily A member 4 , 256 kDa golgin, Protein 72.1, Trans-Golgi p230

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
      - ARL1 recruits TGN Golgin homodimers (Homo sapiens)
        
        AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
        
        TGN Golgin dimers [cytosol] (Homo sapiens)
        
        GOLGA4 dimer [cytosol] (Homo sapiens)
        
        GOLGA4 [cytosol] (Homo sapiens)
        
        TGN Golgin dimers [cytosol] (Homo sapiens)
        
        GOLGA4 dimer [cytosol] (Homo sapiens)
        
        GOLGA4 [cytosol] (Homo sapiens)
      - Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
        
        AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
        
        TGN Golgin dimers [cytosol] (Homo sapiens)
        
        GOLGA4 dimer [cytosol] (Homo sapiens)
        
        GOLGA4 [cytosol] (Homo sapiens)
        
        RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
        
        AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
        
        TGN Golgin dimers [cytosol] (Homo sapiens)
        
        GOLGA4 dimer [cytosol] (Homo sapiens)
        
        GOLGA4 [cytosol] (Homo sapiens)
      - RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
        
        AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
        
        TGN Golgin dimers [cytosol] (Homo sapiens)
        
        GOLGA4 dimer [cytosol] (Homo sapiens)
        
        GOLGA4 [cytosol] (Homo sapiens)
        
        RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
        
        AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
        
        TGN Golgin dimers [cytosol] (Homo sapiens)
        
        GOLGA4 dimer [cytosol] (Homo sapiens)
        
        GOLGA4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13439 GOLGA4

Gene Names

GOLGA4

Chain

chain:1-2230

Reference Genes

BioGPS Gene:2803 GOLGA4

COSMIC (genes):GOLGA4 GOLGA4

CTD Gene:2803 GOLGA4

dbSNP Gene:2803 GOLGA4

ENSEMBL:ENSG00000144674 GOLGA4

HGNC:4427 GOLGA4

KEGG Gene (Homo sapiens):2803 GOLGA4

Monarch:2803 GOLGA4

NCBI Gene:2803 GOLGA4

OMIM:602509 GOLGA4

UCSC:Q13439 GOLGA4

Reference Transcript

Other Identifiers

0001980270

11719318_a_at

11719319_a_at

11719320_x_at

11744728_a_at

11744729_x_at

11751219_x_at

16938935

201567_s_at

2617042

2617043

2617044

2617045

2617053

2617054

2617066

2617069

2617070

2617071

2617072

2617073

2617075

2617076

2617077

2617078

2617079

2617080

2617081

2617082

2617083

2617089

2617090

2617092

2617093

2617096

2617097

2617098

2617099

2617100

2617101

2617104

2617105

2617109

2617111

2617112

2617113

2617116

2617120

2617121

2617125

2803

32150_at

8078569

A_14_P115937

A_24_P187706

GE62351

GO:0000139

GO:0000902

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005802

GO:0005829

GO:0006810

GO:0008150

GO:0015031

GO:0016020

GO:0016192

GO:0019899

GO:0030154

GO:0040007

GO:0043001

GO:0043226

GO:0045773

GO:0048856

GO:0051020

GO:0070062

ILMN_1776297

PH_hs_0033347

TC03000178.hg

U41740_at

X76942_s_at

g6715599_3p_a_at

Participant Of

hasComponent

GOLGA4 dimer [cytosol]

Other forms of this molecule

p-12Y GOLGA4(1-411)-PDGFRB(527-1106) fusion [plasma membrane]

GOLGA4(1-411)-PDGFRB(527-1106) fusion [plasma membrane]

Inferred To

golga4 [cytosol] (Danio rerio)

golga4 [cytosol] (Xenopus tropicalis)

golg-4 [cytosol] (Caenorhabditis elegans)

GOLGA4 [cytosol] (Bos taurus)

GOLGA4 [cytosol] (Canis familiaris)

GOLGA4 [cytosol] (Gallus gallus)

GOLGA4 [cytosol] (Sus scrofa)

Golgin245 [cytosol] (Drosophila melanogaster)

Golga4 [cytosol] (Mus musculus)

Golga4 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001166184.1, NP_002069.2

OpenTargets

ENSG00000144674

HPA

ENSG00000144674-GOLGA4

GeneCards

Q13439

Ensembl

ENSP00000354486, ENST00000361924, ENST00000356847, ENSG00000144674, ENSP00000349305

PRO

Q13439

PDB

1UPT, 1R4A

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NV70 EXOC1	2	EXOC1 [cytosol] (R-HSA-5623375) EXOC1 [plasma membrane] (R-HSA-2872284)	0.553	2