Reactome | PIP4K2C:PIP4K2C [nucleoplasm]

PIP4K2C:PIP4K2C [nucleoplasm]

Stable Identifier

R-HSA-6811471

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PIP4K2C homodimer

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)
        
        PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Homo sapiens)
        
        PIP4K2 dimers [nucleoplasm] (Homo sapiens)
        
        PIP4K2C:PIP4K2C [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
23758345	Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization Irvine, RF, Clarke, JH	Biochem. J.	2013

Participants

components

x 2 PIP4K2C [nucleoplasm] (Homo sapiens)

Participates

as a candidate of

PIP4K2 dimers [nucleoplasm] (Homo sapiens)

Inferred To

PIP4K2C:PIP4K2C [nucleoplasm] (Bos taurus)

PIP4K2C:PIP4K2C [nucleoplasm] (Caenorhabditis elegans)

PIP4K2C:PIP4K2C [nucleoplasm] (Canis familiaris)

PIP4K2C:PIP4K2C [nucleoplasm] (Danio rerio)

PIP4K2C:PIP4K2C [nucleoplasm] (Dictyostelium discoideum)

PIP4K2C:PIP4K2C [nucleoplasm] (Drosophila melanogaster)

PIP4K2C:PIP4K2C [nucleoplasm] (Mus musculus)

PIP4K2C:PIP4K2C [nucleoplasm] (Plasmodium falciparum)

PIP4K2C:PIP4K2C [nucleoplasm] (Rattus norvegicus)

PIP4K2C:PIP4K2C [nucleoplasm] (Saccharomyces cerevisiae)

PIP4K2C:PIP4K2C [nucleoplasm] (Schizosaccharomyces pombe)

PIP4K2C:PIP4K2C [nucleoplasm] (Sus scrofa)

PIP4K2C:PIP4K2C [nucleoplasm] (Xenopus tropicalis)

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