Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
VPS54 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6811032
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Vacuolar protein sorting-associated protein 54, Hepatocellular carcinoma protein 8, Tumor antigen HOM-HCC-8, Tumor antigen SLP-8p
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS54 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS54 [trans-Golgi network membrane] (Homo sapiens)
Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS54 [trans-Golgi network membrane] (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS54 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS54 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS54 [trans-Golgi network membrane] (Homo sapiens)
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS54 [trans-Golgi network membrane] (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS54 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P1Q0 VPS54
Gene Names
VPS54, HCC8
Chain
chain:1-977
Reference Genes
BioGPS Gene:51542 VPS54
COSMIC (genes):VPS54 VPS54
CTD Gene:51542 VPS54
dbSNP Gene:51542 VPS54
ENSEMBL:ENSG00000143952 VPS54
HGNC:18652 VPS54
KEGG:hsa:51542 VPS54
Monarch:51542 VPS54
NCBI Gene:51542 VPS54
OMIM:614633 VPS54
UCSC:Q9P1Q0 VPS54
Reference Transcript
RefSeq:NM_001005739.1 VPS54
RefSeq:NM_016516.2 VPS54
Participates
as a component of
GARP complex [trans-Golgi network membrane] (Homo sapiens)
Inferred To
VPS54 [trans-Golgi network membrane]
(Bos taurus)
VPS54 [trans-Golgi network membrane]
(Canis familiaris)
VPS54 [trans-Golgi network membrane]
(Gallus gallus)
VPS54 [trans-Golgi network membrane]
(Saccharomyces cerevisiae)
VPS54 [trans-Golgi network membrane]
(Sus scrofa)
Vps54 [trans-Golgi network membrane]
(Mus musculus)
Vps54 [trans-Golgi network membrane]
(Rattus norvegicus)
vps-54 [trans-Golgi network membrane]
(Caenorhabditis elegans)
scat [trans-Golgi network membrane]
(Drosophila melanogaster)
vps54 [trans-Golgi network membrane]
(Danio rerio)
vps54 [trans-Golgi network membrane]
(Dictyostelium discoideum)
vps54 [trans-Golgi network membrane]
(Schizosaccharomyces pombe)
Cross References
ENSEMBL
ENST00000409558
,
ENSP00000386980
,
ENST00000354504
,
ENSP00000272322
,
ENSG00000143952
,
ENSP00000346499
,
ENST00000272322
OpenTargets
ENSG00000143952
GeneCards
VPS54
HPA
ENSG00000143952-VPS54
PRO
Q9P1Q0
Pharos - Targets
Q9P1Q0
GlyGen
Q9P1Q0
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text