RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)

Stable Identifier
Reaction [binding]
Homo sapiens
RNA polymerase II binds TBP:TFIIB:TFIIA:TFIIE:TFIIF:snTAFc:CDK7:SNAPc:POU2F1:ZNF143:RNU1-1,RNU2-1 gene
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The basal initiation factors TFIIA, TFIIB, TFIIE, TFIIF, and TBP:snTAFc recruit unphosphorylated RNA polymerase II to the promoter of the (U1, U2, U4, U5) snRNA gene (Gunderson et al. 1990, Kuhlman et al. 1999, Zaborowska et al. 2012).

Literature References
PubMed ID Title Journal Year
22441827 A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes

Zaborowska, J, Taylor, A, Roeder, RG, Murphy, S

Transcription 2012
2125285 The human U1 snRNA promoter correctly initiates transcription in vitro and is activated by PSE1

Gunderson, SI, Knuth, MW, Burgess, RR

Genes Dev. 1990
10022900 The general transcription factors IIA, IIB, IIF, and IIE are required for RNA polymerase II transcription from the human U1 small nuclear RNA promoter

Kuhlman, TC, Cho, H, Reinberg, D, Hernandez, N

Mol. Cell. Biol. 1999
Participant Of
Orthologous Events
Cite Us!