PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PECR associated with the peroxisomal membrane catalyzes the NADPH-dependent reduction of 2E-phytenoyl-CoA to form phytanoyl-CoA (Das et al. 2000; Gloerich et al. 2006). The active form of the enzyme is inferred to be a homotetramer from unpublished data deposited in PDB (accession 1YXM). This reaction is part of the process by which dietary phytol, ultimately derived from chlorophyll, is catabolized (Van Veldhoven 2010).

Literature References
PubMed ID Title Journal Year
16546181 Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation

Ruiter, JP, Wanders, RJA, Gloerich, J, Ferdinandusse, S, Ofman, R, van den Brink, DM

FEBS Lett. 2006
20558530 Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism

Van Veldhoven, PP

J. Lipid Res. 2010
10811639 Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs

Hajra, AK, Uhler, MD, Das, AK

J. Biol. Chem. 2000
Catalyst Activity

trans-2-enoyl-CoA reductase (NADPH) activity of PECR tetramer [peroxisomal membrane]

Orthologous Events
Cite Us!