Reactome | PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA

PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA

Stable Identifier

R-HSA-6809810

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal membrane, peroxisomal matrix

Synonyms

a (2E)-enoyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)

ReviewStatus

5/5

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PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA

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PECR associated with the peroxisomal membrane catalyzes the NADPH-dependent reduction of 2E-phytenoyl-CoA to form phytanoyl-CoA (Das et al. 2000; Gloerich et al. 2006). The active form of the enzyme is inferred to be a homotetramer from unpublished data deposited in PDB (accession 1YXM). This reaction is part of the process by which dietary phytol, ultimately derived from chlorophyll, is catabolized (Van Veldhoven 2010).

Literature References

PubMed ID	Title	Journal	Year
16546181	Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation Gloerich, J, Ruiter, JP, van den Brink, DM, Ofman, R, Ferdinandusse, S, Wanders, RJA	FEBS Lett.	2006
20558530	Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism Van Veldhoven, PP	J. Lipid Res.	2010
10811639	Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs Das, AK, Uhler, MD, Hajra, AK	J. Biol. Chem.	2000