Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GNLY [phagocytic vesicle lumen]
Stable Identifier
R-HSA-6807564
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
phagocytic vesicle lumen
Synonyms
Granulysin, Lymphokine LAG-2, Protein NKG5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
GNLY binds the bacterial cell surface in the phagosome (Homo sapiens)
GNLY [phagocytic vesicle lumen] (Homo sapiens)
GNLY:bacterial anionic lipids [phagocytic vesicle lumen] (Homo sapiens)
GNLY [phagocytic vesicle lumen] (Homo sapiens)
GNLY is transferred to the phagosome (Homo sapiens)
GNLY [phagocytic vesicle lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22749 GNLY
Gene Names
GNLY, LAG2, NKG5, TLA519
Chain
signal peptide:1-22, chain:23-145
Reference Genes
BioGPS Gene:10578 GNLY
COSMIC (genes):GNLY GNLY
CTD Gene:10578 GNLY
dbSNP Gene:10578 GNLY
ENSEMBL:ENSG00000115523 GNLY
HGNC:4414 GNLY
KEGG:hsa:10578 GNLY
Monarch:10578 GNLY
NCBI Gene:10578 GNLY
OMIM:188855 GNLY
UCSC:P22749 GNLY
Reference Transcript
RefSeq:NM_001302758.1 GNLY
RefSeq:NM_012483.3 GNLY
RefSeq:NM_006433.4 GNLY
Other Identifiers
10578
11751857_a_at
11756632_a_at
11763715_a_at
11763755_a_at
11763756_x_at
16882332
205495_PM_s_at
205495_s_at
2491746
2491747
2491748
2491749
2491750
2491751
2491752
2491753
2491754
2491755
2491756
2491757
2491758
2491759
2491760
2491761
2491762
2491763
2491765
2491766
37145_PM_at
37145_at
8043236
A_14_P139337
A_14_P200066
A_23_P209954
A_33_P3353921
GE58500
GE83776
GO:0002376
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0006968
GO:0031640
GO:0042742
GO:0043226
GO:0044194
GO:0050832
GO:0061844
GO:0097013
GO:0098542
HMNXSV003022833
HMNXSV003055507
ILMN_1708779
ILMN_1790692
M85276_at
PH_hs_0005887
TC02000516.hg
g7108343_3p_s_at
Participates
as a component of
GNLY:bacterial anionic lipids [phagocytic vesicle lumen] (Homo sapiens)
as an input of
GNLY binds the bacterial cell surface in the phagosome (Homo sapiens)
as an output of
GNLY is transferred to the phagosome (Homo sapiens)
Other forms of this molecule
GNLY [extracellular region]
Inferred To
nkl.4 [phagocytic vesicle lumen]
(Danio rerio)
GNLY [phagocytic vesicle lumen]
(Bos taurus)
GNLY [phagocytic vesicle lumen]
(Canis familiaris)
GNLY [phagocytic vesicle lumen]
(Gallus gallus)
GNLY [phagocytic vesicle lumen]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000409696
,
ENSG00000115523
,
ENST00000263863
,
ENSP00000263863
,
ENSP00000387116
OpenTargets
ENSG00000115523
GeneCards
GNLY
HPA
ENSG00000115523-GNLY
PRO
P22749
Pharos - Targets
P22749
PDB
1L9L
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96Q80 DERL3
1
DERL3 [endoplasmic reticulum membrane]
(R-HSA-8866516)
0.556
3
UniProt:Q07817 BCL2L1
2
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
BCL2L1 [cytosol]
(R-HSA-50771)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text