EBP isomerizes ZYMSTNL to LTHSOL

Stable Identifier
Reaction [transition]
Homo sapiens
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EBP (3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase) associated with the endoplasmic reticulum membrane catalyzes the conversion of ZYMSTNL (zymostenol) to LTHSOL (lathosterol) (Braverman et al. 1999; Derry et al. 1999; Kandutsch & Russell 1960; Mitsche et al. 2015).

Literature References
PubMed ID Title Journal Year
14404284 Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol

Russell, AE, Kandutsch, AA

J. Biol. Chem. 1960
10391219 Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hunermann syndrome

Wilcox, WR, Obie, C, Lin, P, Valle, D, Moser, A, Moebius, FF, Rimoin, DL, Glossmann, H, Braverman, N, Kratz, L, Kelley, RI, Smith, M

Nat Genet 1999
10391218 Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com.

Boyd, Y, Herman, GE, Gormally, E, Zhao, W, Means, GD, Derry, JM, Kelley, RI, Meindl, A

Nat Genet 1999
26114596 Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Hobbs, HH, Mitsche, MA, Cohen, JC, McDonald, JG

Elife 2015
Catalyst Activity

steroid delta-isomerase activity of EBP [endoplasmic reticulum membrane]

Orthologous Events
Cross References
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