EBP isomerizes ZYMSTNL to LTHSOL

Stable Identifier
R-HSA-6807052
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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EBP (3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase) associated with the endoplasmic reticulum membrane catalyzes the conversion of ZYMSTNL (zymostenol) to LTHSOL (lathosterol) (Braverman et al. 1999; Derry et al. 1999; Kandutsch & Russell 1960; Mitsche et al. 2015).

Literature References
PubMed ID Title Journal Year
10391219 Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hunermann syndrome

Braverman, N, Lin, P, Moebius, FF, Obie, C, Moser, A, Glossmann, H, Wilcox, WR, Rimoin, DL, Smith, M, Kratz, L, Kelley, RI, Valle, D

Nat Genet 1999
14404284 Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol

Kandutsch, AA, Russell, AE

J. Biol. Chem. 1960
10391218 Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com.

Derry, JM, Gormally, E, Means, GD, Zhao, W, Meindl, A, Kelley, RI, Boyd, Y, Herman, GE

Nat Genet 1999
26114596 Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Mitsche, MA, McDonald, JG, Hobbs, HH, Cohen, JC

Elife 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid delta-isomerase activity of EBP [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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