Reactome | EBP isomerizes ZYMSTNL to LTHSOL

EBP isomerizes ZYMSTNL to LTHSOL

Stable Identifier

R-HSA-6807052

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

5alpha-cholest-8-en-3beta-ol => lathosterol

ReviewStatus

5/5

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EBP (3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase) associated with the endoplasmic reticulum membrane catalyzes the conversion of ZYMSTNL (zymostenol) to LTHSOL (lathosterol) (Braverman et al. 1999; Derry et al. 1999; Kandutsch & Russell 1960; Mitsche et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
14404284	Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol Kandutsch, AA, Russell, AE	J. Biol. Chem.	1960
10391219	Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hunermann syndrome Braverman, N, Lin, P, Moebius, FF, Obie, C, Moser, A, Glossmann, H, Wilcox, WR, Rimoin, DL, Smith, M, Kratz, L, Kelley, RI, Valle, D	Nat Genet	1999
10391218	Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Derry, JM, Gormally, E, Means, GD, Zhao, W, Meindl, A, Kelley, RI, Boyd, Y, Herman, GE	Nat Genet	1999
26114596	Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways Mitsche, MA, McDonald, JG, Hobbs, HH, Cohen, JC	Elife	2015