Reactome | Keratin tetramers bind to form unit length filaments

Keratin tetramers bind to form unit length filaments

Stable Identifier

R-HSA-6806613

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Keratin tetramers bind to form unit length filaments

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Mammalian keratins form soluble short full-width filaments called unit length full-width particles (Parry et al. 2007), unit length filaments (ULFs) (Herrmann et al. 2002) or intermediate filament-like particles (Steinert 1991). These are formed by the lateral association of tetramers. ULFs are ~ 70 nm long, with a diameter of ~20 nm. The diameter shrinks during formation of filaments (Parry et al. 2001). X-ray diffraction suggests that ULFs are tube-like structures formed from eight tetramers in non-cornified cells (Parry et al. 2007). In cornified hair cells, the tetramers are thought to be arranged in a seven-member ring, with an eighth in the centre (Parry et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17521629	Towards a molecular description of intermediate filament structure and assembly Parry, DA, Strelkov, SV, Aebi, U, Burkhard, P, Herrmann, H	Exp. Cell Res.	2007
1691188	Differential extraction of keratin subunits and filaments from normal human epidermis Eichner, R, Kahn, M	J. Cell Biol.	1990