Keratin tetramers bind to form unit length filaments

Stable Identifier
R-HSA-6806613
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Mammalian keratins form soluble short full-width filaments called unit length full-width particles (Parry et al. 2007), unit length filaments (ULFs) (Herrmann et al. 2002) or intermediate filament-like particles (Steinert 1991). These are formed by the lateral association of tetramers. ULFs are ~ 70 nm long, with a diameter of ~20 nm. The diameter shrinks during formation of filaments (Parry et al. 2001). X-ray diffraction suggests that ULFs are tube-like structures formed from eight tetramers in non-cornified cells (Parry et al. 2007). In cornified hair cells, the tetramers are thought to be arranged in a seven-member ring, with an eighth in the centre (Parry et al. 2007).

Literature References
PubMed ID Title Journal Year
1691188 Differential extraction of keratin subunits and filaments from normal human epidermis

Eichner, R, Kahn, M

J. Cell Biol. 1990
17521629 Towards a molecular description of intermediate filament structure and assembly

Parry, DA, Strelkov, SV, Burkhard, P, Aebi, U, Herrmann, H

Exp. Cell Res. 2007
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