TP53 stimulates FANCC expression

Stable Identifier
R-HSA-6806425
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 stimulates FANCC expression
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TP53 (p53) stimulates transcription of the FANCC (Fanconi anemia group C) gene, involved in the Fanconi anemia pathway that repairs DNA interstrand crosslinks, by binding to the p53 response element in the FANCC promoter (Liebetrau et al. 1997).
Literature References
PubMed ID Title Journal Year
9063748 p53 activates Fanconi anemia group C gene expression

Grummt, F, Hoehn, H, Savoia, A, Liebetrau, W, Budde, A

Hum. Mol. Genet. 1997
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:FANCC Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-23)
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