TP53 and AP-1 bind the MSH2 promoter

Stable Identifier
R-HSA-6806412
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 and AP-1 bind the MSH2 promoter
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TP53 (p53) binds to the p53 response element in the promoter of the MSH2 gene. The p53 response element is flanked by two AP-1 sites. The AP-1 transcription factor complex binds the MSH2 promoter cooperatively with TP53 (Scherer et al. 2000). An additional p53 response element in closer proximity to the MSH2 transcription start site has been reported that does not involve a nearby AP-1 binding site (Warnick et al. 2001).
Literature References
PubMed ID Title Journal Year
10984493 p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV

Scherer, SJ, Maier, SM, Seifert, M, Hanselmann, RG, Zang, KD, Müller-Hermelink, HK, Angel, P, Welter, C, Schartl, M

J. Biol. Chem. 2000
11350971 Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells

Warnick, CT, Dabbas, B, Ford, CD, Strait, KA

J. Biol. Chem. 2001
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Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-23)
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