TP53 and the AP-1 transcription factor complex cooperatively stimulate transcription of the MSH2 gene, involved in DNA mismatch repair, by binding to adjacent sites in the MSH2 promoter (Scherer et al. 2001). TP53 may stimulate transcription of MSH2 independently of the AP-1 complex when bound to a different p53 response element in the MSH2 promoter (Warnick et al. 2001).
Warnick, CT, Dabbas, B, Ford, CD, Strait, KA
Scherer, SJ, Maier, SM, Seifert, M, Hanselmann, RG, Zang, KD, Müller-Hermelink, HK, Angel, P, Welter, C, Schartl, M
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