TP53 and AP-1 stimulate MSH2 expression

Stable Identifier
R-HSA-6806394
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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TP53 and AP-1 stimulate MSH2 expression
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TP53 and the AP-1 transcription factor complex cooperatively stimulate transcription of the MSH2 gene, involved in DNA mismatch repair, by binding to adjacent sites in the MSH2 promoter (Scherer et al. 2001). TP53 may stimulate transcription of MSH2 independently of the AP-1 complex when bound to a different p53 response element in the MSH2 promoter (Warnick et al. 2001).

Literature References
PubMed ID Title Journal Year
10984493 p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV

Maier, SM, Seifert, M, Angel, P, Scherer, SJ, Zang, KD, Müller-Hermelink, HK, Hanselmann, RG, Welter, C, Schartl, M

J. Biol. Chem. 2000
11350971 Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells

Dabbas, B, Strait, KA, Ford, CD, Warnick, CT

J. Biol. Chem. 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
AP-1:p-S15,S20-TP53 Tetramer:MSH2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
AP-1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-22)
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