Reactome | KAT6A acetylates TP53

KAT6A acetylates TP53

Stable Identifier

R-HSA-6805638

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        KAT6A acetylates TP53 (Homo sapiens)

General

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KAT6A histone acetyltransferase, part of the MOZ/MORF complex, acetylates TP53 (p53) on lysine residues K120 and K382. The acetylation of TP53 by KAT6A is enhanced in the presence of PML and results in increased transcriptional activation of the CDKN1A (p21) gene by TP53 (Rokudai et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23431171	MOZ increases p53 acetylation and premature senescence through its complex formation with PML Rokudai, S, Laptenko, O, Arnal, SM, Taya, Y, Kitabayashi, I, Prives, C	Proc. Natl. Acad. Sci. U.S.A.	2013