KAT6A acetylates TP53

Stable Identifier
R-HSA-6805638
Type
Reaction
Species
Homo sapiens
Compartment
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KAT6A histone acetyltransferase, part of the MOZ/MORF complex, acetylates TP53 (p53) on lysine residues K120 and K382. The acetylation of TP53 by KAT6A is enhanced in the presence of PML and results in increased transcriptional activation of the CDKN1A (p21) gene by TP53 (Rokudai et al. 2013).

Literature References
PubMed ID Title Journal Year
23431171 MOZ increases p53 acetylation and premature senescence through its complex formation with PML

Taya, Y, Rokudai, S, Prives, C, Arnal, SM, Laptenko, O, Kitabayashi, I

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participates
Catalyst Activity

acetyltransferase activity of KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm]

Orthologous Events
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