KAT6A histone acetyltransferase, part of the MOZ/MORF complex, acetylates TP53 (p53) on lysine residues K120 and K382. The acetylation of TP53 by KAT6A is enhanced in the presence of PML and results in increased transcriptional activation of the CDKN1A (p21) gene by TP53 (Rokudai et al. 2013).
Taya, Y, Rokudai, S, Prives, C, Arnal, SM, Laptenko, O, Kitabayashi, I
acetyltransferase activity of KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm]
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