KAT6A and PML bind TP53

Stable Identifier
Reaction [binding]
Homo sapiens
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The histone acetyltransferase KAT6A, which functions as part of the MOZ/MORF complex (Ullah et al. 2008), associates with TP53 (p53) and PML (Rokudai et al. 2013). KAT6A can independently associate with TP53 and PML, but the presence of PML enhances KAT6A-mediated acetylation of TP53. Phosphorylation of KAT6A by activated AKT inhibits PML binding (Rokudai et al. 2013).

Literature References
PubMed ID Title Journal Year
18794358 Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes

Ullah, M, Pelletier, N, Xiao, L, Zhao, SP, Wang, K, Degerny, C, Tahmasebi, S, Cayrou, C, Doyon, Y, Goh, SL, Champagne, N, Côté, J, Yang, XJ

Mol. Cell. Biol. 2008
23431171 MOZ increases p53 acetylation and premature senescence through its complex formation with PML

Rokudai, S, Laptenko, O, Arnal, SM, Taya, Y, Kitabayashi, I, Prives, C

Proc. Natl. Acad. Sci. U.S.A. 2013
Participant Of
This event is regulated
Orthologous Events
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