Reactome | KAT6A and PML bind TP53

KAT6A and PML bind TP53

Stable Identifier

R-HSA-6805620

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        KAT6A and PML bind TP53 (Homo sapiens)

General

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The histone acetyltransferase KAT6A, which functions as part of the MOZ/MORF complex (Ullah et al. 2008), associates with TP53 (p53) and PML (Rokudai et al. 2013). KAT6A can independently associate with TP53 and PML, but the presence of PML enhances KAT6A-mediated acetylation of TP53. Phosphorylation of KAT6A by activated AKT inhibits PML binding (Rokudai et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23431171	MOZ increases p53 acetylation and premature senescence through its complex formation with PML Taya, Y, Rokudai, S, Prives, C, Arnal, SM, Laptenko, O, Kitabayashi, I	Proc. Natl. Acad. Sci. U.S.A.	2013
18794358	Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes Yang, XJ, Côté, J, Wang, K, Goh, SL, Pelletier, N, Degerny, C, Tahmasebi, S, Xiao, L, Cayrou, C, Zhao, SP, Champagne, N, Doyon, Y, Ullah, M	Mol. Cell. Biol.	2008