RNF34 or RFFL ubiquitinates phosphorylated TP53

Stable Identifier
R-HSA-6804441
Type
Reaction
Species
Homo sapiens
Compartment
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E3 ubiquitin ligases RNF34 (CARP1) and RFFL (CARP2) can ubiquitinate TP53 (p53) phosphorylated at the N-terminus and target it for proteasome-mediated degradation (Yang et al. 2007).

Literature References
PubMed ID Title Journal Year
17121812 CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation

Dicker, DT, Wang, W, Liu, JJ, McDonald, ER, Navaraj, A, Yang, W, El-Deiry, WS, Matthew, EM, Rozan, LM

J. Biol. Chem. 2007
Participants
Participates
Catalyst Activity

ubiquitin protein ligase activity of RNF34,RFFL [nucleoplasm]

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