Reactome | RNF34 or RFFL ubiquitinates phosphorylated TP53

RNF34 or RFFL ubiquitinates phosphorylated TP53

Stable Identifier

R-HSA-6804441

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)

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RNF34 or RFFL ubiquitinates phosphorylated TP53

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E3 ubiquitin ligases RNF34 (CARP1) and RFFL (CARP2) can ubiquitinate TP53 (p53) phosphorylated at the N-terminus and target it for proteasome-mediated degradation (Yang et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17121812	CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation Yang, W, Rozan, LM, McDonald, ER, Navaraj, A, Liu, JJ, Matthew, EM, Wang, W, Dicker, DT, El-Deiry, WS	J. Biol. Chem.	2007