E3 ubiquitin ligases RNF34 (CARP1) and RFFL (CARP2) can ubiquitinate TP53 (p53) phosphorylated at the N-terminus and target it for proteasome-mediated degradation (Yang et al. 2007).
Dicker, DT, Wang, W, Liu, JJ, McDonald, ER, Navaraj, A, Yang, W, El-Deiry, WS, Matthew, EM, Rozan, LM
ubiquitin protein ligase activity of RNF34,RFFL [nucleoplasm]
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