RNF34 or RFFL ubiquitinates phosphorylated TP53

Stable Identifier
R-HSA-6804441
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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RNF34 or RFFL ubiquitinates phosphorylated TP53
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E3 ubiquitin ligases RNF34 (CARP1) and RFFL (CARP2) can ubiquitinate TP53 (p53) phosphorylated at the N-terminus and target it for proteasome-mediated degradation (Yang et al. 2007).

Literature References
PubMed ID Title Journal Year
17121812 CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation

Yang, W, Rozan, LM, McDonald, ER, Navaraj, A, Liu, JJ, Matthew, EM, Wang, W, Dicker, DT, El-Deiry, WS

J. Biol. Chem. 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RNF34,RFFL [nucleoplasm]
Physical Entity
RNF34,RFFL [nucleoplasm]
Activity
ubiquitin protein ligase activity (0061630)
Orthologous Events
RNF34 or RFFL ubiquitinates phosphorylated TP53 (Bos taurus)
RNF34 or RFFL ubiquitinates phosphorylated TP53 (Danio rerio)
RNF34 or RFFL ubiquitinates phosphorylated TP53 (Drosophila melanogaster)
RNF34 or RFFL ubiquitinates phosphorylated TP53 (Mus musculus)
RNF34 or RFFL ubiquitinates phosphorylated TP53 (Rattus norvegicus)
RNF34 or RFFL ubiquitinates phosphorylated TP53 (Sus scrofa)
RNF34 or RFFL ubiquitinates phosphorylated TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-10)
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