Reactome | MDM2 ubiquitinates JMY

MDM2 ubiquitinates JMY

Stable Identifier

R-HSA-6804253

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        MDM2 ubiquitinates JMY (Homo sapiens)

General

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MDM2 can bind and ubiquitinate JMY, a transcriptional co-factor of TP53 (p53), thus targeting it for proteasome-mediated degradation (Coutts et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17170761	Mdm2 targets the p53 transcription cofactor JMY for degradation Coutts, AS, Boulahbel, H, Graham, A, La Thangue, NB	EMBO Rep.	2007

Participants

Input

Output

PolyUb-JMY [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Regulation of TP53 Activity through Methylation

Catalyst Activity

Title

ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]

Physical Entity

p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]

Activity

ubiquitin protein ligase activity (0061630)

Orthologous Events

MDM2 ubiquitinates JMY (Bos taurus)

MDM2 ubiquitinates JMY (Canis familiaris)

MDM2 ubiquitinates JMY (Gallus gallus)

MDM2 ubiquitinates JMY (Mus musculus)

MDM2 ubiquitinates JMY (Rattus norvegicus)

MDM2 ubiquitinates JMY (Sus scrofa)

MDM2 ubiquitinates JMY (Xenopus tropicalis)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-09)