MDM2 ubiquitinates JMY

Stable Identifier
R-HSA-6804253
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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MDM2 ubiquitinates JMY
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MDM2 can bind and ubiquitinate JMY, a transcriptional co-factor of TP53 (p53), thus targeting it for proteasome-mediated degradation (Coutts et al. 2007).

Literature References
PubMed ID Title Journal Year
17170761 Mdm2 targets the p53 transcription cofactor JMY for degradation

Coutts, AS, Boulahbel, H, Graham, A, La Thangue, NB

EMBO Rep. 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
Physical Entity
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
Activity
ubiquitin protein ligase activity (0061630)
Orthologous Events
MDM2 ubiquitinates JMY (Canis familiaris)
MDM2 ubiquitinates JMY (Gallus gallus)
MDM2 ubiquitinates JMY (Mus musculus)
MDM2 ubiquitinates JMY (Rattus norvegicus)
MDM2 ubiquitinates JMY (Sus scrofa)
MDM2 ubiquitinates JMY (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-09)
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