MDM2 ubiquitinates JMY

Stable Identifier
R-HSA-6804253
Type
Reaction
Species
Homo sapiens
Compartment
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MDM2 can bind and ubiquitinate JMY, a transcriptional co-factor of TP53 (p53), thus targeting it for proteasome-mediated degradation (Coutts et al. 2007).

Literature References
PubMed ID Title Journal Year
17170761 Mdm2 targets the p53 transcription cofactor JMY for degradation

Coutts, AS, Boulahbel, H, Graham, A, La Thangue, NB

EMBO Rep. 2007
Participants
Participates
Catalyst Activity

ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]

Orthologous Events
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Reviewed
Created
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