MDM2 can bind and ubiquitinate JMY, a transcriptional co-factor of TP53 (p53), thus targeting it for proteasome-mediated degradation (Coutts et al. 2007).
Coutts, AS, Boulahbel, H, Graham, A, La Thangue, NB
ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
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