Nitrite ion and HNO2 form a conjugated acid-base pair

Stable Identifier
R-HSA-6803998
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle lumen
ReviewStatus
5/5
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Nitrite ion and HNO2 form a conjugated acid-base pair
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In the acidic conditions nitrite (NO2-) and nitrous acid (HNO2) present as a conjugated acid-base pair. HNO2 can further react with an additional HNO2 to produce N2O3 (Oldreive C & Rice-Evans C. 2001). N2O3 formation regulates the function of many target proteins through the coupling of a nitroso moiety (NO+) to a reactive cysteine, ultimately leading to the formation of RSNO, a process commonly known as S-nitrosylation (Broniowska KA & Hogg N 2012).

Literature References
PubMed ID Title Journal Year
9950804 Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites:implications in inflammation

Grisham, MB, Jourd'Heuil, D, Wink, DA

Am. J. Physiol. 1999
11697121 The mechanisms for nitration and nitrotyrosine formation in vitro and in vivo: impact of diet

Rice-Evans, C, Oldreive, C

Free Radic. Res. 2001
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Authored
Shamovsky, V  (2018-10-23)
Reviewed
Nüsse, O  (2018-11-07)
Created
Shamovsky, V  (2015-10-08)
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