Reactome | TP53 binds the PLAGL1 gene

TP53 binds the PLAGL1 gene

Stable Identifier

R-HSA-6803935

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        TP53 binds the PLAGL1 gene (Homo sapiens)

General

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TP53 binds the p53 response element in the promoter of the PLAGL1 (ZAC1) gene (Rozenfeld-Granot et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11896574	A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1 Amariglio, N, Kannan, K, Rechavi, G, Toren, A, Givol, D, Krishnamurthy, J, Rozenfeld-Granot, G	Oncogene	2002

Participants

Input

Output

p-S15,S20-TP53 Tetramer:PLAGL1 Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-07)

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