Reactome | TP53 binds the RGCC gene

TP53 binds the RGCC gene

Stable Identifier

R-HSA-6803914

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        TP53 binds the RGCC gene (Homo sapiens)

General

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TP53 (p53) binds to the p53 response element in the second intron of the RGCC (RGC32) gene (Saigusa et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17146433	RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest Saigusa, K, Tanikawa, C, Inazawa, J, Aoyagi, M, Nakamura, Y, Ohno, K, Imoto, I	Oncogene	2007

Participants

Input

Output

p-S15,S20-TP53 Tetramer:RGCC Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-07)

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