Reactome | SFN dimer binds BAX

SFN dimer binds BAX

Stable Identifier

R-HSA-6803892

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        SFN dimer binds BAX (Homo sapiens)

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SFN (14-3-3-sigma) dimer forms a complex with BAX. Binding of SFN to BAX prevents BAX translocation from cytosol to mitochondria, thus inhibiting cytochrome C release and apoptosis. SFN therefore promotes G2 cell cycle arrest while simultaneously preventing apoptosis (Samuel et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11574543	The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax Funk, JO, Eppel, JT, Weber, HO, Samuel, T, McShea, A, Rauch, P, Verdoodt, B, Hermeking, H	J. Biol. Chem.	2001