SFN (14-3-3-sigma) dimer forms a complex with BAX. Binding of SFN to BAX prevents BAX translocation from cytosol to mitochondria, thus inhibiting cytochrome C release and apoptosis. SFN therefore promotes G2 cell cycle arrest while simultaneously preventing apoptosis (Samuel et al. 2001).
Funk, JO, Eppel, JT, Weber, HO, Samuel, T, McShea, A, Rauch, P, Verdoodt, B, Hermeking, H
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