Reactome | SFN dimer binds BAX

SFN dimer binds BAX

Stable Identifier

R-HSA-6803892

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
        
        SFN dimer binds BAX (Homo sapiens)

General

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SFN (14-3-3-sigma) dimer forms a complex with BAX. Binding of SFN to BAX prevents BAX translocation from cytosol to mitochondria, thus inhibiting cytochrome C release and apoptosis. SFN therefore promotes G2 cell cycle arrest while simultaneously preventing apoptosis (Samuel et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11574543	The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax Samuel, T, Weber, HO, Rauch, P, Verdoodt, B, Eppel, JT, McShea, A, Hermeking, H, Funk, JO	J. Biol. Chem.	2001

Participants

Input

Output

SFN Dimer:BAX [cytosol] (Homo sapiens)

Participant Of

hasEvent

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

Orthologous Events

SFN dimer binds BAX (Bos taurus)

SFN dimer binds BAX (Canis familiaris)

SFN dimer binds BAX (Danio rerio)

SFN dimer binds BAX (Mus musculus)

SFN dimer binds BAX (Rattus norvegicus)

SFN dimer binds BAX (Xenopus tropicalis)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-07)