SFN dimer binds BAX

Stable Identifier
R-HSA-6803892
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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SFN dimer binds BAX
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SFN (14-3-3-sigma) dimer forms a complex with BAX. Binding of SFN to BAX prevents BAX translocation from cytosol to mitochondria, thus inhibiting cytochrome C release and apoptosis. SFN therefore promotes G2 cell cycle arrest while simultaneously preventing apoptosis (Samuel et al. 2001).

Literature References
PubMed ID Title Journal Year
11574543 The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax

Funk, JO, Eppel, JT, Weber, HO, Samuel, T, McShea, A, Rauch, P, Verdoodt, B, Hermeking, H

J. Biol. Chem. 2001
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Orthologous Events
SFN dimer binds BAX (Canis familiaris)
SFN dimer binds BAX (Danio rerio)
SFN dimer binds BAX (Mus musculus)
SFN dimer binds BAX (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-07)
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