SFN dimer binds BAX

Stable Identifier
R-HSA-6803892
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SFN dimer binds BAX
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SFN (14-3-3-sigma) dimer forms a complex with BAX. Binding of SFN to BAX prevents BAX translocation from cytosol to mitochondria, thus inhibiting cytochrome C release and apoptosis. SFN therefore promotes G2 cell cycle arrest while simultaneously preventing apoptosis (Samuel et al. 2001).
Literature References
PubMed ID Title Journal Year
11574543 The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax

Samuel, T, Weber, HO, Rauch, P, Verdoodt, B, Eppel, JT, McShea, A, Hermeking, H, Funk, JO

J. Biol. Chem. 2001
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Orthologous Events
SFN dimer binds BAX (Bos taurus)
SFN dimer binds BAX (Danio rerio)
SFN dimer binds BAX (Mus musculus)
SFN dimer binds BAX (Rattus norvegicus)
SFN dimer binds BAX (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-07)
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