DCD(63-110) is processed to DCD(63-109)

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
A 47aa dermcidin (DCD)-derived peptide (DCD(63-109), also known as as DCD-1) is an antimicrobial peptide with a negative net charge and acidic pI (Schittek B 2012). Like other antimicrobially active DCD-derived peptides, DCD(63-109) is produced in human eccrine sweat through proteolytic processing of a 110-amino acid (aa) precursor protein (Schittek B et al. 2001; Rieg S et al. 2006). DCD-derived peptides are able to bind to the bacterial surface, however they do not exert their activity by permeabilizing bacterial membranes (SenyĆ¼rek et al. 2009, Steffen H et al. 2006). The negative net charge of DCD(63-109) did not significantly affected the peptide binding to bacterial-mimetic membranes (Jung et al. 2010, Steffen et al. 2006; Senyurek et al. 2009). Spin-down assays of DCD(63-109) and other DCD peptides revealed that the affinity with which dermcidin binds to bacterial-mimetic membranes is primarily dependent on its amphipathic alpha-helical structure and its length (>30 residues)(Jung et al. 2010).

DCD(63-109) shows a broad spectrum of antimicrobial activity against Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Staphylococcus epidermidis, Listeria monocytogenes) and Gram-negative bacteria (Escherichia coli, Pseudomonas putida, Salmonella typhimurium) as well as Candida albicans (Cipakova I et al. 2006, Lai YP et al. 2005, Schittek B et al. 2001, Steffen H et al. 2006, Vuong C et al. 2004). The activity of the DCD(63-109) was maintained over a broad pH range and in high salt concentrations that resembled the conditions in human sweat (Schittek B et al. 2001).

Literature References
PubMed ID Title Journal Year
16354654 Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L

Baechle, D, Kalbacher, H, Steffen, H, Cansier, A, Flad, T, Mueller, GA, Tolson, J, Garbe, C, Herrmann, T, Mueller, CA, Schittek, B, Dihazi, H, Stevanovic, S, Beck, A, Mueller, M

J. Biol. Chem. 2006
22455996 The multiple facets of dermcidin in cell survival and host defense

Schittek, B

J Innate Immun 2012
16374474 Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites

Kimura, A, Seeber, S, Rieg, S, Schittek, B, Kalbacher, H, Steffen, H, Stevanovic, S, Garbe, C, Humeny, A

J. Invest. Dermatol. 2006
Catalyst Activity

peptidase activity of unknown peptidase [cytosol]

Cite Us!