DCD(63-110) is processed to DCD(63-109)

Stable Identifier
R-HSA-6803060
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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DCD(63-110) is processed to DCD(63-109)
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A 47aa dermcidin (DCD)-derived peptide (DCD(63-109), also known as as DCD-1) is an antimicrobial peptide with a negative net charge and acidic pI (Schittek B 2012). Like other antimicrobially active DCD-derived peptides, DCD(63-109) is produced in human eccrine sweat through proteolytic processing of a 110-amino acid (aa) precursor protein (Schittek B et al. 2001; Rieg S et al. 2006). DCD-derived peptides are able to bind to the bacterial surface, however they do not exert their activity by permeabilizing bacterial membranes (Senyürek et al. 2009, Steffen H et al. 2006). The negative net charge of DCD(63-109) did not significantly affected the peptide binding to bacterial-mimetic membranes (Jung et al. 2010, Steffen et al. 2006; Senyurek et al. 2009). Spin-down assays of DCD(63-109) and other DCD peptides revealed that the affinity with which dermcidin binds to bacterial-mimetic membranes is primarily dependent on its amphipathic alpha-helical structure and its length (>30 residues)(Jung et al. 2010).

DCD(63-109) shows a broad spectrum of antimicrobial activity against Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Staphylococcus epidermidis, Listeria monocytogenes) and Gram-negative bacteria (Escherichia coli, Pseudomonas putida, Salmonella typhimurium) as well as Candida albicans (Cipakova I et al. 2006, Lai YP et al. 2005, Schittek B et al. 2001, Steffen H et al. 2006, Vuong C et al. 2004). The activity of the DCD(63-109) was maintained over a broad pH range and in high salt concentrations that resembled the conditions in human sweat (Schittek B et al. 2001).

Literature References
PubMed ID Title Journal Year
16354654 Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L

Baechle, D, Kalbacher, H, Steffen, H, Cansier, A, Flad, T, Mueller, GA, Tolson, J, Garbe, C, Herrmann, T, Mueller, CA, Schittek, B, Dihazi, H, Stevanovic, S, Beck, A, Mueller, M

J. Biol. Chem. 2006
22455996 The multiple facets of dermcidin in cell survival and host defense

Schittek, B

J Innate Immun 2012
16374474 Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites

Kimura, A, Seeber, S, Rieg, S, Schittek, B, Kalbacher, H, Steffen, H, Stevanovic, S, Garbe, C, Humeny, A

J. Invest. Dermatol. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peptidase activity of unknown peptidase [cytosol]

Physical Entity
unknown peptidase [cytosol] (Homo sapiens)
Activity
peptidase activity (GO:0008233)
Authored
Shamovsky, V  (2015-10-05)
Reviewed
Jupe, S  (2016-04-15)
Hains, DS  (2016-08-02)
Created
Shamovsky, V  (2015-10-04)
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