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p-S621 RAF1:YWHAB [cytosol]
Stable Identifier
R-HSA-6802713
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
p-S621 RAF1:YWHAB [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)
inactive RAF1,BRAF [cytosol] (Homo sapiens)
p-S621 RAF1:YWHAB [cytosol] (Homo sapiens)
RAS mutants bind inactive RAF (Homo sapiens)
inactive RAF1,BRAF [cytosol] (Homo sapiens)
p-S621 RAF1:YWHAB [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)
'receiver' RAF [cytosol] (Homo sapiens)
p-S621 RAF1:YWHAB [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane] (Homo sapiens)
'receiver' RAF [cytosol] (Homo sapiens)
p-S621 RAF1:YWHAB [cytosol] (Homo sapiens)
RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane] (Homo sapiens)
'receiver' RAF [cytosol] (Homo sapiens)
p-S621 RAF1:YWHAB [cytosol] (Homo sapiens)
Participants
components
p-S621-RAF1 [cytosol] (Homo sapiens)
YWHAB [cytosol] (Homo sapiens)
Participant Of
input
Inactive BRAF mutants:mutant RAS:GTP bind RAF1
hasMember
'receiver' RAF [cytosol]
hasCandidate
inactive RAF1,BRAF [cytosol]
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