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genetically or chemically inactive BRAF [cytosol]
Stable Identifier
R-HSA-6802631
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
Participants
members
WT BRAF:inhibitors [cytosol]
(Homo sapiens)
kinase dead BRAF mutants [cytosol]
(Homo sapiens)
Participates
as an input of
Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
as a component of
mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
cardiofaciocutaneous syndrome
DOID:0060233
CFC syndrome, cardio-facial-cutaneous syndrome
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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