REG3A binds bacterial phospholipids

Stable Identifier
R-HSA-6801776
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Structural studies of human REG3A by X-ray diffraction with electron microscopy suggest that REG3A binds to bacterial membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing pore (Mukherjee S et al. 2014).

Literature References
PubMed ID Title Journal Year
24256734 Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Mukherjee, S, Zheng, H, Derebe, MG, Callenberg, KM, Partch, CL, Rollins, D, Propheter, DC, Rizo, J, Grabe, M, Jiang, QX, Hooper, LV

Nature 2014
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