REG3A binds bacterial phospholipids

Stable Identifier
R-HSA-6801776
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, peptidoglycan-based cell wall
ReviewStatus
5/5
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REG3A binds bacterial phospholipids
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Structural studies of human REG3A by X-ray diffraction with electron microscopy suggest that REG3A binds to bacterial membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing pore (Mukherjee S et al. 2014).
Literature References
PubMed ID Title Journal Year
24256734 Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Partch, CL, Callenberg, KM, Grabe, M, Derebe, MG, Zheng, H, Jiang, QX, Mukherjee, S, Hooper, LV, Rollins, D, Rizo, J, Propheter, DC

Nature 2014
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Orthologous Events
REG3A binds bacterial phospholipids (Bos taurus)
REG3A binds bacterial phospholipids (Caenorhabditis elegans)
REG3A binds bacterial phospholipids (Canis familiaris)
REG3A binds bacterial phospholipids (Drosophila melanogaster)
REG3A binds bacterial phospholipids (Mus musculus)
REG3A binds bacterial phospholipids (Rattus norvegicus)
REG3A binds bacterial phospholipids (Sus scrofa)
REG3A binds bacterial phospholipids (Xenopus tropicalis)
Authored
Shamovsky, V  (2015-10-05)
Reviewed
Jupe, S  (2016-04-15)
Hains, DS  (2016-08-02)
Created
Shamovsky, V  (2015-10-02)
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