Reactome | TP53 binds the PLK2 gene

TP53 binds the PLK2 gene

Stable Identifier

R-HSA-6801641

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        TP53 binds the PLK2 gene (Homo sapiens)

General

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TP53 (p53) can bind three p53 binding sites in the promoter of the PLK2 gene (Burns et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12897130	Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells Dicker, DT, Scata, KA, Fei, P, Burns, TF, El-Deiry, WS	Mol. Cell. Biol.	2003

Participants

Input

Output

p-S15,S20-TP53 Tetramer:PLK2 Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-02)

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