Reactome | STEAP3 binds BNIP3L

STEAP3 binds BNIP3L

Stable Identifier

R-HSA-6801195

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane, mitochondrial outer membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        STEAP3 binds BNIP3L (Homo sapiens)

General

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STEAP3 (TSAP6) forms a complex with a pro-apoptotic protein BNIP3L (NIX) and cooperates with BNIP3L in promoting apoptosis, but the exact mechanism is not known (Passer et al. 2003).

While STEAP3 localizes to endosome membranes, BNIP3L localizes to the outer mitochondrial membrane. BNIP3L has recently been implicated in the relocalization of endo-lysosomes to inner mitochondrial compartments, which can play a role in endo-lysosomal processing of mitochondria (Hamacher-Brady et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25080938	Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase Choe, SC, Krijnse-Locker, J, Brady, NR, Hamacher-Brady, A	Cell Death Differ.	2014
12606722	The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase Roborel de Climens, A, Cans, C, Prieur, S, Passer, BJ, Susini, L, Dausset, J, Nancy-Portebois, V, Amson, R, Bouvard, V, Morchoisne, S, Fiucci, G, Telerman, A, Tuynder, M, Crible, V, Lespagnol, A, Amzallag, N, Oren, M	Proc. Natl. Acad. Sci. U.S.A.	2003