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ZNF420 binds TP53AIP1 gene
Stable Identifier
R-HSA-6798624
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
ZNF420 binds TP53AIP1 gene (Homo sapiens)
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The transcription factor ZNF420 (Apak) has a binding site in the first intron of the TP53AIP1 gene that overlaps with the p53 response element. The binding of ZNF420 interferes with the binding of TP53 and results in the repression of TP53AIP1 transcription (Yuan et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
22334068
Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis
Tian, C
,
Wang, H
,
Song, S
,
Xing, G
,
Yin, Y
,
He, F
,
Li, D
,
Yuan, L
,
Zhang, L
EMBO Rep.
2012
Participants
Input
TP53AIP1 Gene [nucleoplasm]
(Homo sapiens)
ZNF420 [nucleoplasm]
(Homo sapiens)
Output
ZNF420:TP53AIP1 Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
Authored
Orlic-Milacic, M (2015-10-14)
Reviewed
Zaccara, S (2016-02-04)
Inga, A (2016-02-04)
Created
Orlic-Milacic, M (2015-09-19)
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