MDM2 ubiquitinates DYRK2

Stable Identifier
R-HSA-6798373
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MDM2 ubiquitinates DYRK2
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MDM2 ubiquitinates DYRK2 in the nucleus, leading to proteasome-mediated degradation of DYRK2. This results in the removal of nuclear DYRK2 and exclusive localization of DYRK2 in the cytosol in the absence of DNA damage. ATM-mediated phosphorylation of DYRK2 prevents ubiquitination of DYRK2 by MDM2, leading to accumulation of nuclear DYRK2 (Taira et al. 2010).
Literature References
PubMed ID Title Journal Year
19965871 ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage

Taira, N, Yamamoto, H, Yamaguchi, T, Miki, Y, Yoshida, K

J. Biol. Chem. 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]

Physical Entity
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
MDM2 ubiquitinates DYRK2 (Bos taurus)
MDM2 ubiquitinates DYRK2 (Canis familiaris)
MDM2 ubiquitinates DYRK2 (Danio rerio)
MDM2 ubiquitinates DYRK2 (Gallus gallus)
MDM2 ubiquitinates DYRK2 (Mus musculus)
MDM2 ubiquitinates DYRK2 (Rattus norvegicus)
MDM2 ubiquitinates DYRK2 (Sus scrofa)
MDM2 ubiquitinates DYRK2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-19)
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