E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter

Stable Identifier
R-HSA-6798347
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

E2F7 binds to E2F sites in the promoter of the E2F1 gene to inhibit its expression (Di Stefano et al. 2003, Carvajal et al. 2012, Aksoy et al. 2012). Besides E2F7 homodimers, heterodimers of E2F7 and E2F8, as well as E2F8 homodimers, can also bind to the promoter of the E2F1 gene to inhibit its transcription (Li et al. 2008, Zalmas et al. 2008).

Literature References
PubMed ID Title Journal Year
22802529 The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

Aksoy, O, Chicas, A, Zeng, T, Zhao, Z, McCurrach, M, Wang, X, Lowe, SW

Genes Dev. 2012
22802528 E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

Carvajal, LA, Hamard, PJ, Tonnessen, C, Manfredi, JJ

Genes Dev. 2012
18202719 DNA-damage response control of E2F7 and E2F8

Zalmas, LP, Zhao, X, Graham, AL, Fisher, R, Reilly, C, Coutts, AS, La Thangue, NB

EMBO Rep. 2008
18194653 Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development

Li, J, Ran, C, Li, E, Gordon, F, Comstock, G, Siddiqui, H, Cleghorn, W, Chen, HZ, Kornacker, K, Liu, CG, Pandit, SK, Khanizadeh, M, Weinstein, M, Leone, G, de Bruin, A

Dev. Cell 2008
14633988 E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

Di Stefano, L, Jensen, MR, Helin, K

EMBO J. 2003
Participants
Input
Output
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Di Stefano, L  (2017-01-03)
Westendorp, B  (2017-01-24)
de Bruin, A  (2017-01-24)
Created
Orlic-Milacic, M  (2015-09-18)
Cite Us!