TP53 stimulates E2F7 expression

Stable Identifier
R-HSA-6798299
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 stimulates E2F7 expression
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Binding of TP53 (p53) to the p53 response element in the promoter of the E2F7 gene stimulates E2F7 transcription (Carvajal et al. 2012, Aksoy et al. 2012).
Literature References
PubMed ID Title Journal Year
22802528 E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

Carvajal, LA, Hamard, PJ, Tonnessen, C, Manfredi, JJ

Genes Dev. 2012
22802529 The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

Aksoy, O, Chicas, A, Zeng, T, Zhao, Z, McCurrach, M, Wang, X, Lowe, SW

Genes Dev. 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:E2F7 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-18)
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