LRRTMs bind NRXNs

Stable Identifier
R-HSA-6797974
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The LRRTM (leucine-rich repeat (LRR) transmembrane neuronal) are a small family of paralogous LRR containing cell surface receptors. This family has four members (LRRTM 1-4) that share similar domain structure with an extracellular domain containing ten extracellular leucine-rich repeats that mediate protein-protein interactions, followed by a single transmembrane domain and a short c-terminal sequence containing a class I PDZ-domain-binding motif. LRRTMs are predominantely expressed in the nervous system. All four LRRTMs family members are post-synaptic localized and bind specifically to presynaptic alpha and beta-Neurexins (NRXNs) lacking an insert at splice site S4 (Siddiqui et al. 2010). Neuroligins bind NRXN containing or lacking an insert in S4, LRRTMs bind only NRXNs lacking an insert in this splicing site (de Wit et al. 2009, Ko et al. 2009).

Literature References
PubMed ID Title Journal Year
20064387 LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation

Ko, J, Fuccillo, MV, Malenka, RC, Südhof, TC

Neuron 2009
20519524 LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development

Siddiqui, TJ, Pancaroglu, R, Kang, Y, Rooyakkers, A, Craig, AM

J. Neurosci. 2010
20064388 LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation

de Wit, J, Sylwestrak, E, O'Sullivan, ML, Otto, S, Tiglio, K, Savas, JN, Yates, JR, Comoletti, D, Taylor, P, Ghosh, A

Neuron 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed