Reactome | LRRTMs bind NRXNs

LRRTMs bind NRXNs

Stable Identifier

R-HSA-6797974

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The LRRTM (leucine-rich repeat (LRR) transmembrane neuronal) are a small family of paralogous LRR containing cell surface receptors. This family has four members (LRRTM 1-4) that share similar domain structure with an extracellular domain containing ten extracellular leucine-rich repeats that mediate protein-protein interactions, followed by a single transmembrane domain and a short c-terminal sequence containing a class I PDZ-domain-binding motif. LRRTMs are predominantely expressed in the nervous system. All four LRRTMs family members are post-synaptic localized and bind specifically to presynaptic alpha and beta-Neurexins (NRXNs) lacking an insert at splice site S4 (Siddiqui et al. 2010). Neuroligins bind NRXN containing or lacking an insert in S4, LRRTMs bind only NRXNs lacking an insert in this splicing site (de Wit et al. 2009, Ko et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
20519524	LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development Siddiqui, TJ, Pancaroglu, R, Kang, Y, Rooyakkers, A, Craig, AM	J. Neurosci.	2010
20064387	LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation Ko, J, Fuccillo, MV, Malenka, RC, Südhof, TC	Neuron	2009
20064388	LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation de Wit, J, Sylwestrak, E, O'Sullivan, ML, Otto, S, Tiglio, K, Savas, JN, Yates, JR, Comoletti, D, Taylor, P, Ghosh, A	Neuron	2009