Reactome | SLC22A4 transports BET from mitochondrial matrix to cytosol

SLC22A4 transports BET from mitochondrial matrix to cytosol

Stable Identifier

R-HSA-6797957

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial matrix

Synonyms

glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in), BET translocates from mitochondrial matrix to cytosol

ReviewStatus

5/5

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SLC22A4 transports BET from mitochondrial matrix to cytosol

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SLC22A4 (Solute carrier family 22 member 4) associated with the mitochondrial membrane transports betaine (BET) plus a sodium ion from the mitochondrial matrix to the cytosol (Lamhonwah & Tein 2006, Wagner et al. 2000, Yee et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
16729965	Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria Lamhonwah, AM, Tein, I	Biochem Biophys Res Commun	2006
10966938	Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2 Wagner, CA, Lükewille, U, Kaltenbach, S, Moschen, I, Bröer, A, Risler, T, Bröer, S, Lang, F	Am J Physiol Renal Physiol	2000
33124720	Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies Yee, SW, Buitrago, D, Stecula, A, Ngo, HX, Chien, HC, Zou, L, Koleske, ML, Giacomini, KM	FASEB J	2020