NRXNs bind CASK:Protein 4.1

Stable Identifier
R-HSA-6797568
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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NRXNs bind CASK:Protein 4.1
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In neurons, CASK forms a stable tripartite complex with brain-enriched Veli proteins and brain-specific Mint1 and anchors this complex to neurexins (Butz et al. 1998). CASK also binds to a brain-enriched isoform of protein 4.1, and nucleates local assembly of actin/spectrin filaments. Neurexins are recruited together with CASK and protein 4.1 into these actin filaments and thus intercellular junctions initiated by neurexins with neuroligins are at least partially coupled to the actin cytoskeleton (Biederer & Sudhof 2001).

Literature References
PubMed ID Title Journal Year
11604393 CASK and protein 4.1 support F-actin nucleation on neurexins

Südhof, TC, Biederer, T

J. Biol. Chem. 2001
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Orthologous Events
NRXNs bind CASK:Protein 4.1 (Bos taurus)
NRXNs bind CASK:Protein 4.1 (Caenorhabditis elegans)
NRXNs bind CASK:Protein 4.1 (Canis familiaris)
NRXNs bind CASK:Protein 4.1 (Danio rerio)
NRXNs bind CASK:Protein 4.1 (Mus musculus)
NRXNs bind CASK:Protein 4.1 (Rattus norvegicus)
NRXNs bind CASK:Protein 4.1 (Sus scrofa)
Authored
Garapati, P V  (2015-09-04)
Reviewed
Washbourne, P  (2015-11-09)
Created
Garapati, P V  (2015-09-14)
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