In neurons, CASK forms a stable tripartite complex with brain-enriched Veli proteins and brain-specific Mint1 and anchors this complex to neurexins (Butz et al. 1998). CASK also binds to a brain-enriched isoform of protein 4.1, and nucleates local assembly of actin/spectrin filaments. Neurexins are recruited together with CASK and protein 4.1 into these actin filaments and thus intercellular junctions initiated by neurexins with neuroligins are at least partially coupled to the actin cytoskeleton (Biederer & Sudhof 2001).
Biederer, T, Südhof, TC
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