Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NRXNs bind CASK:Protein 4.1
Stable Identifier
R-HSA-6797568
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
NRXNs bind CASK:Protein 4.1 (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In neurons, CASK forms a stable tripartite complex with brain-enriched Veli proteins and brain-specific Mint1 and anchors this complex to neurexins (Butz et al. 1998). CASK also binds to a brain-enriched isoform of protein 4.1, and nucleates local assembly of actin/spectrin filaments. Neurexins are recruited together with CASK and protein 4.1 into these actin filaments and thus intercellular junctions initiated by neurexins with neuroligins are at least partially coupled to the actin cytoskeleton (Biederer & Sudhof 2001).
Literature References
PubMed ID
Title
Journal
Year
11604393
CASK and protein 4.1 support F-actin nucleation on neurexins
Südhof, TC
,
Biederer, T
J. Biol. Chem.
2001
Participants
Input
CASK:Protein 4.1 [cytosol]
(Homo sapiens)
NRXNs:NLGN dimers [plasma membrane]
(Homo sapiens)
Output
NRXNs:NLGN dimers:CASK:Protein 4.1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Neurexins and neuroligins (Homo sapiens)
Orthologous Events
NRXNs bind CASK:Protein 4.1 (Bos taurus)
NRXNs bind CASK:Protein 4.1 (Caenorhabditis elegans)
NRXNs bind CASK:Protein 4.1 (Canis familiaris)
NRXNs bind CASK:Protein 4.1 (Danio rerio)
NRXNs bind CASK:Protein 4.1 (Drosophila melanogaster)
NRXNs bind CASK:Protein 4.1 (Mus musculus)
NRXNs bind CASK:Protein 4.1 (Rattus norvegicus)
NRXNs bind CASK:Protein 4.1 (Sus scrofa)
NRXNs bind CASK:Protein 4.1 (Xenopus tropicalis)
Authored
Garapati, P V (2015-09-04)
Reviewed
Washbourne, P (2015-11-09)
Created
Garapati, P V (2015-09-14)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text