ABP1 binds SHANK proteins

Stable Identifier
R-HSA-6797554
Type
Reaction [binding]
Species
Homo sapiens
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At the PSD (postsynaptic density), activity-dependent reorganizations of the cortical actin cytoskeleton are hypothesized to play a role in synaptic plasticity. Drebrin-like protein (DBNL) (also referred as Filamentous actin (F-actin)-binding protein 1 (ABP1)), which controls Arp2/3 complex-mediated actin nucleation binds to postsynaptic scaffold proteins of the ProSAP (proline-rich synapse-associated protein 1)/Shank family. This DBNL–ProSAP/Shank complexes serve to connect synaptic signal reception to postsynaptic structural plasticity via rearrangements of the actin cytoskeleton in spines (Haeckel et al. 2008).

Literature References
PubMed ID Title Journal Year
18829961 The actin-binding protein Abp1 controls dendritic spine morphology and is important for spine head and synapse formation

Haeckel, A, Ahuja, R, Gundelfinger, ED, Qualmann, B, Kessels, MM

J. Neurosci. 2008
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