Expression of IL18, ALOX5

Stable Identifier
R-HSA-6797293
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Expression of IL18, ALOX5
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In human peripheral blood, monocytes Interleukin-4 (IL4) and Interleukin-13 significantly downregulate the expression of classical proinflammatory signal transducers, such as Interleukin-1 (IL1), Interleukin-6, Interleukin-8, Interleukin-18, C-C motif chemokine 2 (CCL2) and Tumor necrosis factor (TNF). Expression of Prostaglandin G/H synthase 2 (PTGS2, COX2) and Arachidonate 5-lipoxygenase (ALOX5), enzymes involved in the biosynthesis of the proinflammatory eicosanoids, is also attenuated (Chatidis et al. 2005).
This is a black box event because the mechanism of gene regulation is not fully defined.
Literature References
PubMed ID Title Journal Year
15869882 Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13

Chaitidis, P, Bermudez-Fajardo, A, Kuban, RJ, O'Donnell, V, Kühn, H, Ungethuem, U

Cytokine 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
IL4, IL13 [extracellular region] (Homo sapiens)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-09-07)
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