Reactome | TORC2 complex phosphorylates SGK1

TORC2 complex phosphorylates SGK1

Stable Identifier

R-HSA-6795290

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        TORC2 complex phosphorylates SGK1 (Homo sapiens)

General

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The TORC2 complex phosphorylates SGK1 at serine residue S422, located in the carboxy-terminal hydrophobic motif of SGK1. Phosphorylation at S422 contributes to SGK1 activation (Garcia-Martinez and Alessi 2008, Lu et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20338997	mTOR complex-2 activates ENaC by phosphorylating SGK1 Jones, KT, Shokat, KM, Ashrafi, K, Wang, J, Yao, LJ, Lu, M, Feldman, ME, Pearce, D, Ives, HE	J. Am. Soc. Nephrol.	2010
18925875	mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1) Alessi, DR, García-Martínez, JM	Biochem. J.	2008