TORC2 complex phosphorylates SGK1

Stable Identifier
R-HSA-6795290
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The TORC2 complex phosphorylates SGK1 at serine residue S422, located in the carboxy-terminal hydrophobic motif of SGK1. Phosphorylation at S422 contributes to SGK1 activation (Garcia-Martinez and Alessi 2008, Lu et al. 2010).

Literature References
PubMed ID Title Journal Year
18925875 mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

García-Martínez, JM, Alessi, DR

Biochem. J. 2008
20338997 mTOR complex-2 activates ENaC by phosphorylating SGK1

Lu, M, Wang, J, Jones, KT, Ives, HE, Feldman, ME, Yao, LJ, Shokat, KM, Ashrafi, K, Pearce, D

J. Am. Soc. Nephrol. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of TORC2 complex [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created