The TORC2 complex phosphorylates SGK1 at serine residue S422, located in the carboxy-terminal hydrophobic motif of SGK1. Phosphorylation at S422 contributes to SGK1 activation (Garcia-Martinez and Alessi 2008, Lu et al. 2010).
García-Martínez, JM, Alessi, DR
Lu, M, Wang, J, Jones, KT, Ives, HE, Feldman, ME, Yao, LJ, Shokat, KM, Ashrafi, K, Pearce, D
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