TORC2 complex phosphorylates SGK1

Stable Identifier
R-HSA-6795290
Type
Reaction
Species
Homo sapiens
Compartment
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The TORC2 complex phosphorylates SGK1 at serine residue S422, located in the carboxy-terminal hydrophobic motif of SGK1. Phosphorylation at S422 contributes to SGK1 activation (Garcia-Martinez and Alessi 2008, Lu et al. 2010).

Literature References
PubMed ID Title Journal Year
20338997 mTOR complex-2 activates ENaC by phosphorylating SGK1

Jones, KT, Shokat, KM, Ashrafi, K, Wang, J, Yao, LJ, Lu, M, Feldman, ME, Pearce, D, Ives, HE

J. Am. Soc. Nephrol. 2010
18925875 mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Alessi, DR, García-Martínez, JM

Biochem. J. 2008
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of TORC2 complex [cytosol]

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