Reactome | mTORC2 phosphorylates SGK1

mTORC2 phosphorylates SGK1

Stable Identifier

R-HSA-6795290

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        mTORC2 phosphorylates SGK1 (Homo sapiens)

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The TORC2 complex phosphorylates SGK1 at serine residue S422, located in the carboxy-terminal hydrophobic motif of SGK1. Phosphorylation at S422 contributes to SGK1 activation (Garcia-Martinez and Alessi 2008, Lu et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20338997	mTOR complex-2 activates ENaC by phosphorylating SGK1 Lu, M, Wang, J, Jones, KT, Ives, HE, Feldman, ME, Yao, LJ, Shokat, KM, Ashrafi, K, Pearce, D	J. Am. Soc. Nephrol.	2010
18925875	mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1) García-Martínez, JM, Alessi, DR	Biochem. J.	2008