LIPH, I hydrolyse PA to 2-acyl LPA

Stable Identifier
R-HSA-6792445
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Lipase members H and I (LIPH, I) specifically hydrolyse phosphatidic acid (PA) to the potent bioactive lipid mediator 2-acyl lysophosphatidic acid (2-acyl LPA) (Hiramatsu et al. 2003, Sonoda et al. 2002). LIPH is expressed in most tissues at low levels whereas LIPI is mainly expressed in the testis.

Literature References
PubMed ID Title Journal Year
12963729 Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta

Hiramatsu, T, Sonoda, H, Takanezawa, Y, Morikawa, R, Ishida, M, Kasahara, K, Sanai, Y, Taguchi, R, Aoki, J, Arai, H

J. Biol. Chem. 2003
12063250 A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid

Sonoda, H, Aoki, J, Hiramatsu, T, Ishida, M, Bandoh, K, Nagai, Y, Taguchi, R, Inoue, K, Arai, H

J. Biol. Chem. 2002
Participants
Participates
Catalyst Activity

phospholipase activity of LIPH, I [plasma membrane]

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