Reactome | LIPH, I hydrolyse PA to 2-acyl LPA

LIPH, I hydrolyse PA to 2-acyl LPA

Stable Identifier

R-HSA-6792445

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Lipase members H and I (LIPH, I) specifically hydrolyse phosphatidic acid (PA) to the potent bioactive lipid mediator 2-acyl lysophosphatidic acid (2-acyl LPA) (Hiramatsu et al. 2003, Sonoda et al. 2002). LIPH is expressed in most tissues at low levels whereas LIPI is mainly expressed in the testis.

Literature References

PubMed ID	Title	Journal	Year
12063250	A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid Bandoh, K, Nagai, Y, Sonoda, H, Ishida, M, Taguchi, R, Arai, H, Inoue, K, Hiramatsu, T, Aoki, J	J. Biol. Chem.	2002
12963729	Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta Kasahara, K, Sonoda, H, Ishida, M, Taguchi, R, Arai, H, Morikawa, R, Takanezawa, Y, Aoki, J, Hiramatsu, T, Sanai, Y	J. Biol. Chem.	2003