Reactome | TP53 stimulates ARID3A gene expression

TP53 stimulates ARID3A gene expression

Stable Identifier

R-HSA-6791363

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        TP53 stimulates ARID3A gene expression (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TP53 (p53) stimulates transcription of the ARID3A gene upon binding to the p53 response element in the second intron of the ARID3A gene (Ma et al. 2003). ARID3A is implicated as both a positive and a negative cell cycle regulator. It interacts with E2F1 and stimulates E2F1 transcriptional activity (Suzuki et al. 1998, Peeper et al. 2002). It may also cooperate with TP53 in the activation of CDKN1A (p21) transcription (Lestari et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22172947	Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage Lestari, W, Ichwan, SJ, Otsu, M, Yamada, S, Iseki, S, Shimizu, S, Ikeda, MA	Biochem. Biophys. Res. Commun.	2012
12692263	E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53 Ma, K, Araki, K, Ichwan, SJ, Suganuma, T, Tamamori-Adachi, M, Ikeda, MA	Mol. Cancer Res.	2003
11812999	A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence Peeper, DS, Shvarts, A, Brummelkamp, T, Douma, S, Koh, EY, Daley, GQ, Bernards, R	Nat. Cell Biol.	2002
9780002	A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer Suzuki, M, Okuyama, S, Okamoto, S, Shirasuna, K, Nakajima, T, Hachiya, T, Nojima, H, Sekiya, S, Oda, K	Oncogene	1998