TP53 stimulates ARID3A gene expression

Stable Identifier
R-HSA-6791363
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 stimulates ARID3A gene expression
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TP53 (p53) stimulates transcription of the ARID3A gene upon binding to the p53 response element in the second intron of the ARID3A gene (Ma et al. 2003). ARID3A is implicated as both a positive and a negative cell cycle regulator. It interacts with E2F1 and stimulates E2F1 transcriptional activity (Suzuki et al. 1998, Peeper et al. 2002). It may also cooperate with TP53 in the activation of CDKN1A (p21) transcription (Lestari et al. 2012).
Literature References
PubMed ID Title Journal Year
12692263 E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53

Ma, K, Araki, K, Ichwan, SJ, Suganuma, T, Tamamori-Adachi, M, Ikeda, MA

Mol. Cancer Res. 2003
22172947 Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage

Lestari, W, Ichwan, SJ, Otsu, M, Yamada, S, Iseki, S, Shimizu, S, Ikeda, MA

Biochem. Biophys. Res. Commun. 2012
11812999 A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

Peeper, DS, Shvarts, A, Brummelkamp, T, Douma, S, Koh, EY, Daley, GQ, Bernards, R

Nat. Cell Biol. 2002
9780002 A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer

Suzuki, M, Okuyama, S, Okamoto, S, Shirasuna, K, Nakajima, T, Hachiya, T, Nojima, H, Sekiya, S, Oda, K

Oncogene 1998
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:ARID3A Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-08-20)
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