Reactome | TP53 binds the BID gene promoter

TP53 binds the BID gene promoter

Stable Identifier

R-HSA-6791285

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 binds the BID gene promoter (Homo sapiens)

General

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TP53 (p53) binds evolutionarily conserved p53 response elements in the promoter of the BID gene (Sax et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12402042	BID regulation by p53 contributes to chemosensitivity Murphy, ME, Bernhard, E, Fei, P, Korsmeyer, SJ, Sax, JK, El-Deiry, WS	Nat. Cell Biol.	2002

Participants

Input

Output

p-S15,S20-TP53 Tetramer:BID Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-08-20)

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