SUMOylation of XPC

Stable Identifier
Reaction [transition]
Homo sapiens
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XPC undergoes SUMOylation following UV irradiation on several consensus SUMOylation sites (van Cuijk et al. 2015). SUMOylation of XPC probably succeeds the UV-DDB mediated ubiquitination of XPC, as the presence of both DDB2 and XPA is required for SUMOylation (Wang et al. 2005), but it has also been reported that SUMOylation of XPC was DDB2-independent (Akita et al. 2015). It is unclear whether XPC is modified by SUMO1 (Wang et al. 2005, Akita et al. 2015) or poly-SUMO2/3 (Poulsen et al. 2013). SUMO conjugases PIAS1 and PIAS3 both interact with XPC and may catalyze XPC SUMOylation (Akita et al. 2015).

Literature References
PubMed ID Title Journal Year
26042670 SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair

Mori, T, Tak, YS, Iwai, S, Sugasawa, K, Ikura, T, Shimura, T, Akita, M, Hanaoka, F, Nishi, R, Okuda-Shimizu, Y, Saitoh, H, Shimizu, Y, Sakai, W, Matsumoto, S

Sci Rep 2015
16030353 DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation

Wang, QE, El-Mahdy, MA, Zhu, Q, Li, J, Wani, G, Wani, AA

Nucleic Acids Res. 2005
26151477 SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

Houtsmuller, AB, Lans, H, Sabatella, M, Poulsen, SL, Theil, AF, Janssens, RC, van Belle, GJ, Marteijn, JA, van Cuijk, L, Turkyilmaz, Y, Mailand, N, Vermeulen, W

Nat Commun 2015
23751493 RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

Houtsmuller, AB, Poulsen, SL, Hansen, RK, Wikström, M, van Belle, GJ, Marteijn, JA, van Cuijk, L, Streicher, W, Choudhary, C, Bekker-Jensen, S, Mailand, N, Wagner, SA

J. Cell Biol. 2013
Catalyst Activity

SUMO transferase activity of PIAS1,3 [nucleoplasm]

Orthologous Events
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