Reactome | SUMOylation of XPC

SUMOylation of XPC

Stable Identifier

R-HSA-6790454

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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XPC undergoes SUMOylation following UV irradiation on several consensus SUMOylation sites (van Cuijk et al. 2015). SUMOylation of XPC probably succeeds the UV-DDB mediated ubiquitination of XPC, as the presence of both DDB2 and XPA is required for SUMOylation (Wang et al. 2005), but it has also been reported that SUMOylation of XPC was DDB2-independent (Akita et al. 2015). It is unclear whether XPC is modified by SUMO1 (Wang et al. 2005, Akita et al. 2015) or poly-SUMO2/3 (Poulsen et al. 2013). SUMO conjugases PIAS1 and PIAS3 both interact with XPC and may catalyze XPC SUMOylation (Akita et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26042670	SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair Akita, M, Tak, YS, Shimura, T, Matsumoto, S, Okuda-Shimizu, Y, Shimizu, Y, Nishi, R, Saitoh, H, Iwai, S, Mori, T, Ikura, T, Sakai, W, Hanaoka, F, Sugasawa, K	Sci Rep	2015
16030353	DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation Wang, QE, Zhu, Q, Wani, G, El-Mahdy, MA, Li, J, Wani, AA	Nucleic Acids Res.	2005
26151477	SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair van Cuijk, L, van Belle, GJ, Turkyilmaz, Y, Poulsen, SL, Janssens, RC, Theil, AF, Sabatella, M, Lans, H, Mailand, N, Houtsmuller, AB, Vermeulen, W, Marteijn, JA	Nat Commun	2015
23751493	RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response Poulsen, SL, Hansen, RK, Wagner, SA, van Cuijk, L, van Belle, GJ, Streicher, W, Wikström, M, Choudhary, C, Houtsmuller, AB, Marteijn, JA, Bekker-Jensen, S, Mailand, N	J. Cell Biol.	2013