SUMOylation of XPC

Stable Identifier
R-HSA-6790454
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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SUMOylation of XPC
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XPC undergoes SUMOylation following UV irradiation on several consensus SUMOylation sites (van Cuijk et al. 2015). SUMOylation of XPC probably succeeds the UV-DDB mediated ubiquitination of XPC, as the presence of both DDB2 and XPA is required for SUMOylation (Wang et al. 2005), but it has also been reported that SUMOylation of XPC was DDB2-independent (Akita et al. 2015). It is unclear whether XPC is modified by SUMO1 (Wang et al. 2005, Akita et al. 2015) or poly-SUMO2/3 (Poulsen et al. 2013). SUMO conjugases PIAS1 and PIAS3 both interact with XPC and may catalyze XPC SUMOylation (Akita et al. 2015).

Literature References
PubMed ID Title Journal Year
16030353 DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation

Wang, QE, Zhu, Q, Wani, G, El-Mahdy, MA, Li, J, Wani, AA

Nucleic Acids Res. 2005
26042670 SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair

Akita, M, Tak, YS, Shimura, T, Matsumoto, S, Okuda-Shimizu, Y, Shimizu, Y, Nishi, R, Saitoh, H, Iwai, S, Mori, T, Ikura, T, Sakai, W, Hanaoka, F, Sugasawa, K

Sci Rep 2015
26151477 SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

van Cuijk, L, van Belle, GJ, Turkyilmaz, Y, Poulsen, SL, Janssens, RC, Theil, AF, Sabatella, M, Lans, H, Mailand, N, Houtsmuller, AB, Vermeulen, W, Marteijn, JA

Nat Commun 2015
23751493 RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

Poulsen, SL, Hansen, RK, Wagner, SA, van Cuijk, L, van Belle, GJ, Streicher, W, Wikström, M, Choudhary, C, Houtsmuller, AB, Marteijn, JA, Bekker-Jensen, S, Mailand, N

J. Cell Biol. 2013
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1,3 [nucleoplasm]
Physical Entity
PIAS1,3 [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
SUMOylation of XPC (Bos taurus)
SUMOylation of XPC (Caenorhabditis elegans)
SUMOylation of XPC (Canis familiaris)
SUMOylation of XPC (Danio rerio)
SUMOylation of XPC (Dictyostelium discoideum)
SUMOylation of XPC (Drosophila melanogaster)
SUMOylation of XPC (Gallus gallus)
SUMOylation of XPC (Mus musculus)
SUMOylation of XPC (Rattus norvegicus)
SUMOylation of XPC (Sus scrofa)
SUMOylation of XPC (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-08-10)
Reviewed
Fousteri, M  (2015-08-03)
Created
Orlic-Milacic, M  (2015-08-10)