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Expression of IL13-downregulated extracellular proteins
Stable Identifier
R-HSA-6789325
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
,
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of IL13-downregulated extracellular proteins (Homo sapiens)
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IL13 inhibits monocyte and macrophage production of Interleukin-1 (IL1), IL6, IL8, Tumor necrosis factor (TNF) and IL12 (de Vries et al. 1998), through a mechanism that partially involves suppression of Nuclear factor NF-kappa-B.
Literature References
PubMed ID
Title
Journal
Year
9723655
The role of IL-13 and its receptor in allergy and inflammatory responses
de Vries, JE
J. Allergy Clin. Immunol.
1998
Participants
Input
IL13-downregulated genes for extracellular proteins [nucleoplasm]
(Homo sapiens)
Output
IL13-downregulated proteins [extracellular region]
(Homo sapiens)
Participates
as an event of
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
This event is regulated
Negatively by
Regulator
IL13 [extracellular region]
(Homo sapiens)
Authored
Jupe, S (2015-07-01)
Reviewed
Leibovich, SJ (2016-09-02)
Created
Jupe, S (2015-07-30)
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