Reactome | ICMT [endoplasmic reticulum membrane]

ICMT [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-6788651

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Protein-S-isoprenylcysteine O-methyltransferase ecNumber2.1.1.100/ecNumber, ICMT_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O60725 ICMT

Gene Names

ICMT, PCCMT

Chain

chain:1-284

Reference Genes

BioGPS Gene:23463 ICMT

COSMIC (genes):ICMT ICMT

CTD Gene:23463 ICMT

dbSNP Gene:23463 ICMT

ENSEMBL:ENSG00000116237 ICMT

HGNC:5350 ICMT

KEGG:hsa:23463 ICMT

Monarch:23463 ICMT

NCBI Gene:23463 ICMT

OMIM:605851 ICMT

UCSC:O60725 ICMT

Reference Transcript

RefSeq:NM_012405.3 ICMT

Other Identifiers

11716323_at

11716324_a_at

16681082

201609_PM_x_at

201609_x_at

201610_3p_at

201610_PM_at

201610_at

201611_PM_s_at

201611_s_at

23463

2394587

2394589

2394590

2394591

2394592

2394593

2394594

2394595

2394596

2394597

2394598

2394599

2394600

2394601

2394602

2394603

41775_at

7911993

A_23_P104065

A_24_P128524

A_33_P3381022

GE61187

GO:0003824

GO:0003880

GO:0004671

GO:0005515

GO:0005783

GO:0005789

GO:0006481

GO:0006520

GO:0006575

GO:0006612

GO:0006790

GO:0008168

GO:0016020

GO:0016740

GO:0032259

GO:0036211

GO:0043226

GO:0046498

GO:0046499

GO:0055086

GO:0140096

GO:1901135

HMNXSV003028030

HMNXSV003045600

Hs.183212.0.S1_3p_a_at

Hs.183212.0.S3_3p_x_at

ILMN_1723021

ILMN_1744500

PH_hs_0010812

TC01002147.hg

g6912429_3p_a_at

Participates

as a component of

ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

icmt [endoplasmic reticulum membrane] (Danio rerio)

icmt [endoplasmic reticulum membrane] (Xenopus tropicalis)

ICMT [endoplasmic reticulum membrane] (Bos taurus)

ICMT [endoplasmic reticulum membrane] (Caenorhabditis elegans)

ICMT [endoplasmic reticulum membrane] (Dictyostelium discoideum)

ICMT [endoplasmic reticulum membrane] (Gallus gallus)

ICMT [endoplasmic reticulum membrane] (Mus musculus)

ICMT [endoplasmic reticulum membrane] (Plasmodium falciparum)

ICMT [endoplasmic reticulum membrane] (Rattus norvegicus)

ICMT [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

ICMT [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Icmt [endoplasmic reticulum membrane] (Drosophila melanogaster)

Cross References

ENSEMBL

ENST00000343813, ENSP00000343552, ENSG00000116237

OpenTargets

ENSG00000116237

IntEnz

2.1.1.100

GeneCards

ICMT

HPA

ENSG00000116237-ICMT

ZINC - Substances

ICMT_HUMAN

ZINC - Biogenic

ICMT_HUMAN

ZINC target

O60725

PRO

O60725

Pharos - Targets

O60725

ZINC - Predictions - Purchasable

ICMT_HUMAN

HMDB Protein

HMDBP00414

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:O00186 STXBP3	4	p-Y521-STXBP3 [plasma membrane] (R-HSA-2263472) STXBP3 [plasma membrane] (R-HSA-2263473) p-STXBP3 [cytosol] (R-HSA-114680) STXBP3 [cytosol] (R-HSA-114682)	0.527	2