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ICMT [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-6788651
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Protein-S-isoprenylcysteine O-methyltransferase ecNumber2.1.1.100/ecNumber, ICMT_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
ICMT [endoplasmic reticulum membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
Cysmethynil binds ICMT:Zn2+ (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
ICMT [endoplasmic reticulum membrane] (Homo sapiens)
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
ICMT [endoplasmic reticulum membrane] (Homo sapiens)
ICMT methylates S-Farn RAS proteins (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
ICMT [endoplasmic reticulum membrane] (Homo sapiens)
ICMT:Zn2+:Cysmethynil [endoplasmic reticulum membrane] (Homo sapiens)
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
ICMT [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60725 ICMT
Gene Names
ICMT, PCCMT
Chain
chain:1-284
Reference Genes
BioGPS Gene:23463 ICMT
COSMIC (genes):ICMT ICMT
CTD Gene:23463 ICMT
dbSNP Gene:23463 ICMT
ENSEMBL:ENSG00000116237 ICMT
HGNC:5350 ICMT
KEGG:hsa:23463 ICMT
Monarch:23463 ICMT
NCBI Gene:23463 ICMT
OMIM:605851 ICMT
UCSC:O60725 ICMT
Reference Transcript
RefSeq:NM_012405.3 ICMT
Other Identifiers
11716323_at
11716324_a_at
16681082
201609_PM_x_at
201609_x_at
201610_3p_at
201610_PM_at
201610_at
201611_PM_s_at
201611_s_at
23463
2394587
2394589
2394590
2394591
2394592
2394593
2394594
2394595
2394596
2394597
2394598
2394599
2394600
2394601
2394602
2394603
41775_at
7911993
A_23_P104065
A_24_P128524
A_33_P3381022
GE61187
GO:0003824
GO:0003880
GO:0004671
GO:0005515
GO:0005783
GO:0005789
GO:0006481
GO:0006520
GO:0006575
GO:0006612
GO:0006790
GO:0008168
GO:0016020
GO:0016740
GO:0032259
GO:0036211
GO:0043226
GO:0046498
GO:0046499
GO:0055086
GO:0140096
GO:1901135
HMNXSV003028030
HMNXSV003045600
Hs.183212.0.S1_3p_a_at
Hs.183212.0.S3_3p_x_at
ILMN_1723021
ILMN_1744500
PH_hs_0010812
TC01002147.hg
g6912429_3p_a_at
Participates
as a component of
ICMT:Zn2+ [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
icmt [endoplasmic reticulum membrane]
(Danio rerio)
icmt [endoplasmic reticulum membrane]
(Xenopus tropicalis)
ICMT [endoplasmic reticulum membrane]
(Bos taurus)
ICMT [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
ICMT [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
ICMT [endoplasmic reticulum membrane]
(Gallus gallus)
ICMT [endoplasmic reticulum membrane]
(Mus musculus)
ICMT [endoplasmic reticulum membrane]
(Plasmodium falciparum)
ICMT [endoplasmic reticulum membrane]
(Rattus norvegicus)
ICMT [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
ICMT [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
Icmt [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000343813
,
ENSP00000343552
,
ENSG00000116237
OpenTargets
ENSG00000116237
IntEnz
2.1.1.100
GeneCards
ICMT
HPA
ENSG00000116237-ICMT
ZINC - Substances
ICMT_HUMAN
ZINC - Biogenic
ICMT_HUMAN
ZINC target
O60725
PRO
O60725
Pharos - Targets
O60725
ZINC - Predictions - Purchasable
ICMT_HUMAN
HMDB Protein
HMDBP00414
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:O00186 STXBP3
4
p-Y521-STXBP3 [plasma membrane]
(R-HSA-2263472)
STXBP3 [plasma membrane]
(R-HSA-2263473)
p-STXBP3 [cytosol]
(R-HSA-114680)
STXBP3 [cytosol]
(R-HSA-114682)
0.527
2
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