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NLGN2 [plasma membrane]
Stable Identifier
R-HSA-6788639
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Neuroligin-2, NLGN2_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
ABP1 binds SHANK proteins (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
GKAPs bind PSD-95 members (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
HOMER binds SHANK proteins (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NLGNs binds PSD-95 subfamily members (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NRXNs bind CASK:Protein 4.1 (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:CASK:Protein 4.1 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NRXNs bind NLGNs (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
SHANK proteins bind GKAPs (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
NRXNs:NLGN dimers [plasma membrane] (Homo sapiens)
NLGN dimers [plasma membrane] (Homo sapiens)
NLGN2 dimer [plasma membrane] (Homo sapiens)
NLGN2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NFZ4 NLGN2
Gene Names
NLGN2, KIAA1366
Chain
signal peptide:1-14, chain:15-835
Reference Genes
BioGPS Gene:57555 NLGN2
COSMIC (genes):NLGN2 NLGN2
CTD Gene:57555 NLGN2
dbSNP Gene:57555 NLGN2
ENSEMBL:ENSG00000169992 NLGN2
HGNC:14290 NLGN2
KEGG:hsa:57555 NLGN2
Monarch:57555 NLGN2
NCBI Gene:57555 NLGN2
OMIM:606479 NLGN2
UCSC:Q8NFZ4 NLGN2
Reference Transcript
RefSeq:NM_020795.3 NLGN2
Other Identifiers
11717456_x_at
11717457_a_at
11717458_at
11732029_a_at
11732030_at
1554428_3p_s_at
1554428_PM_s_at
1554428_s_at
16830428
16830432
16830441
226288_PM_s_at
226288_s_at
240878_PM_at
240878_at
3708555
3708556
3708557
3708558
3708560
3708561
3708563
3708564
3708565
3708566
3708567
3708568
3708569
3708570
3708571
3708572
3708573
3708574
3708575
3708577
3708579
3708581
3708583
3708584
3708585
3708588
3708590
3708592
3708594
3708596
3708598
3708599
3708600
3708601
51119_at
57555
8004385
8004394
90520_i_at
90521_r_at
A_14_P104656
A_14_P200459
A_21_P0009376
A_21_P0009377
A_23_P207125
GE53933
GE540874
GO:0001966
GO:0002087
GO:0005886
GO:0007155
GO:0007158
GO:0007268
GO:0007416
GO:0007630
GO:0008284
GO:0009986
GO:0016020
GO:0016192
GO:0019233
GO:0023052
GO:0030424
GO:0030425
GO:0032024
GO:0032230
GO:0034330
GO:0034394
GO:0035176
GO:0035418
GO:0035641
GO:0038023
GO:0042043
GO:0042734
GO:0042802
GO:0042995
GO:0043198
GO:0045202
GO:0045211
GO:0045217
GO:0048488
GO:0050804
GO:0050808
GO:0050839
GO:0050877
GO:0050885
GO:0051932
GO:0051965
GO:0051968
GO:0060076
GO:0060077
GO:0060089
GO:0060999
GO:0061024
GO:0072553
GO:0072578
GO:0097104
GO:0097105
GO:0097116
GO:0097119
GO:0097151
GO:0097470
GO:0098609
GO:0098690
GO:0098691
GO:0098698
GO:0098982
GO:0098983
GO:0098984
GO:0099054
GO:0099634
GO:1901142
GO:1902474
GO:1904034
GO:1904862
GO:1905606
GO:2000311
GO:2000463
GO:2000809
HMNXSV003020178
HMNXSV003021759
HMNXSV003030307
HMNXSV003048695
Hs.127075.0.A1_3p_at
Hs.26229.1.A1_3p_a_at
Hs2.380702.1.S1_3p_s_at
ILMN_1764158
ILMN_2056932
PH_hs_0002316
TC17000093.hg
TC17002033.hg
TC17002034.hg
TC17002863.hg
p20252
p20253
Participates
as a component of
NLGN2 dimer [plasma membrane] (Homo sapiens)
Inferred To
Nlg1 [plasma membrane]
(Drosophila melanogaster)
Nlgn2 [plasma membrane]
(Mus musculus)
Nlgn2 [plasma membrane]
(Rattus norvegicus)
Gli [plasma membrane]
(Drosophila melanogaster)
Nlg2 [plasma membrane]
(Drosophila melanogaster)
Homologues of NLGN2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of NLGN2 [plasma membrane]
(Drosophila melanogaster)
glit-1 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG10339 [plasma membrane]
(Drosophila melanogaster)
nlgn2 [plasma membrane]
(Xenopus tropicalis)
NLGN2 [plasma membrane]
(Bos taurus)
NLGN2 [plasma membrane]
(Canis familiaris)
Nlg3 [plasma membrane]
(Drosophila melanogaster)
nlg-1 [plasma membrane]
(Caenorhabditis elegans)
Nlg4 [plasma membrane]
(Drosophila melanogaster)
nlgn2b [plasma membrane]
(Danio rerio)
Cross References
ENSEMBL
ENSP00000492198
,
ENST00000575301
,
ENSP00000461168
,
ENSP00000305288
,
ENSP00000492323
,
ENST00000302926
,
ENST00000639647
,
ENST00000640620
OpenTargets
ENSG00000169992
HPA
ENSG00000169992-NLGN2
PRO
Q8NFZ4
Pharos - Targets
Q8NFZ4
PDB
8GS4
,
5XEQ
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N0Z6 TTC5
3
TTC5 [nucleoplasm]
(R-HSA-6804264)
p-S203-TTC5 [nucleoplasm]
(R-HSA-6804261)
p-S203,S221-TTC5 [nucleoplasm]
(R-HSA-6804259)
0.527
2
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