NUBPL transfers 4Fe-4S to Complex I subunits

Stable Identifier
R-HSA-6788523
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
mitochondrial matrix
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NUBPL transfers 4Fe-4S to Complex I subunits
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In total, eight iron-sulfur (4Fe-4S) clusters are incorporated into six subunits (mitochondrial matrix-located NDUFS1, S2, S7, S8 and mitochondrial membrane-located V1 and V2) (Andrews et al. 2013). Incorporation into NDUFV1 and V2 (located on the mitochondrial membrane) is shown in a separate reaction. The mechanism of transfer in all cases is unknown.

Literature References
PubMed ID Title Journal Year
24191001 Assembly factors for the membrane arm of human complex I

Fearnley, IM, Carroll, J, Andrews, B, Walker, JE, Ding, S

Proc. Natl. Acad. Sci. U.S.A. 2013
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Orthologous Events
NUBPL transfers 4Fe-4S to Complex I subunits (Canis familiaris)
NUBPL transfers 4Fe-4S to Complex I subunits (Danio rerio)
NUBPL transfers 4Fe-4S to Complex I subunits (Dictyostelium discoideum)
NUBPL transfers 4Fe-4S to Complex I subunits (Drosophila melanogaster)
NUBPL transfers 4Fe-4S to Complex I subunits (Gallus gallus)
NUBPL transfers 4Fe-4S to Complex I subunits (Mus musculus)
NUBPL transfers 4Fe-4S to Complex I subunits (Rattus norvegicus)
NUBPL transfers 4Fe-4S to Complex I subunits (Sus scrofa)
Authored
Jassal, B  (2015-07-22)
Reviewed
Meldal, BH  (2015-10-01)
Created
Jassal, B  (2015-07-22)
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